지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 319 - 324 (6page)
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초록· 키워드
오류제보하기
The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense against bacterial infection. To study the role of NODs in the host response to Mycobacterium leprae, we measured the mRNA levels of NODs and related genes in infected mouse tissues. The mRNA expression of NOD1, NOD2, caspase-1 and ASC was increased in mouse footpads. Whereas NOD2 expression in macrophages was increased at 2 and 24 h post-infection with M. leprae, there was no expression of NOD1 at these time points. An increase in caspase-1 expression was observed at 2 h and continued at 24 h. However, the expression of ASC was increased only at the early time point. The expression of caspase-1 is regulated by NOD2-dependent pathway in established HEK 293. Our results suggest NOD2, rather than NOD1, may be associated with the host response to M. leprae and that caspase-1 activation is essential for the host response.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Kang, T. J. / 2002 / A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy / Cytokine 20 : 56 ~ 62
[학술지(정기간행물)] - Kang, T. J. / 2004 / Differential production of interleukin-10 interleukin-12in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation / Immunology 112 : 674 ~ 680
[학술지(정기간행물)] - Philpott, D. J. / 2004 / The role of Toll-like receptors Nod proteins in bacterial infection / Mol. Immunol 41 : 1099 ~ 1108
[학술지(정기간행물)] - Franchi, L. / 2008 / Intracellular NOD-like receptors in innate immunity, infection disease / Cell. Microbiol 10 : 1 ~ 8
[학술지(정기간행물)] - Kanneganti, T. D. / 2007 / Intracellular NOD-like receptors in host defense disease / Immunity 27 : 549 ~ 559
[학술지(정기간행물)] - Kang, T. J. / 2004 / Differential production of interleukin-10 interleukin-12in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation / Immunology 112 : 674 ~ 680
[학술지(정기간행물)] - Philpott, D. J. / 2004 / The role of Toll-like receptors Nod proteins in bacterial infection / Mol. Immunol 41 : 1099 ~ 1108
[학술지(정기간행물)] - Franchi, L. / 2008 / Intracellular NOD-like receptors in innate immunity, infection disease / Cell. Microbiol 10 : 1 ~ 8
[학술지(정기간행물)] - Kanneganti, T. D. / 2007 / Intracellular NOD-like receptors in host defense disease / Immunity 27 : 549 ~ 559
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The Nod2 in essential for host immune defense against Acinetobacter baumannii infection
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The Physical Interaction between Nucleotide-Binding Oligomerization Domain Containing 2 and Leucine-Rich Repeat Kinase 2
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Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils
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Type I IFNs are involved in host defense against pulmonary infection of Mycobacterium abscessus by mediating NOD2-induced production of nitric oxide in macrophages
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Transplantation of human umbilical cord blood CD34+ cells into the liver of newborn NOD/SCID/IL-2Rγ null (NSG) mice after busulfan conditioning
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Two base pair deletion in IL2 receptor γ gene in NOD/SCID mice induces a highly severe immunodeficiency
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A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome
JOURNAL OF BACTERIOLOGY AND VIROLOGY
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Retinoic acid attenuates Sjögren’s syndrome via regulation of IL-17 producing CCR9+T cells and Salivary gland inflammation
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Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages
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Protective effects of Heat killed Lactobacillus sakei CVL-001 on DSS induced colitis mice model
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Identification of Mycobacterium leprae and Mycobacterium lepromatosis in Formalin-Fixed and Paraffin-Embedded Skin Samples from Mexico
Annals of Dermatology
2018 .01
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Pulmonary inflammation caused by silica dioxide nanoparticles in mice via TXNIP/NLRP3 signaling pathway
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Type I Lepra Reaction as the Presenting Sign of Histoid Leprosy
Annals of Dermatology
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Silica dioxide nanoparticles aggravate airway inflammation in asthmatic mice model via NLRP3 inflammsome activation
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microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways
Immune Network
2019 .10
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Caspase-1 Independent Viral Clearance and Adaptive Immunity Against Mucosal Respiratory Syncytial Virus Infection
Immune Network
2015 .04
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Human delta like 1-expressing human mesenchymal stem cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2Rgnull (NSG) mice
한국실험동물학회 학술발표대회 논문집
2022 .01
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NOD-Like Receptors in Infection, Immunity, and Diseases
Yonsei Medical Journal
2016 .01
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UCI(KEPA) : I410-ECN-0101-2016-511-002259000