지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 451 - 456 (6page)
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Background: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). Objective: To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. Methods: This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of GPP and 11 biopsies of 11 cases of AGEP. Through staining with the anti-IL-36-alpha (IL-36α), anti-IL-36 receptor antagonist (IL-36Ra), anti-nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), anti-IL-23, anti-IL-17, and anti-IL-8 antibodies, main expression location and intensity were visualized in the epidermis and dermis. Results: In both diseases, diffuse IL-36α expression was observed in the epidermis. IL-36Ra expression was observed in the dermal perivascular area as well as in the epidermis. NF-κB expression was observed in the epidermis and perivascular dermal area. Diffuse IL-23 and IL-17 expression was seen in the whole epidermis and the perivascular dermal area. IL-8 was expressed in the subcorneal pustules and parakeratotic area.
Contrary to other cytokines, IL-23 expression in the epidermis of patients with GPP was more intense than only that in patients with AGEP. Conclusion: Common pathomechanisms might exist in the development of GPP and AGEP based on these immunohistochemical results, but further studies are needed.
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참고문헌 (28)
참고문헌 신청
Choon SE. / 2014 / Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis : analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia / Int J Dermatol 53:676~684
Varman KM. / 2014 / Acute generalized pustular psoriasis, von Zumbusch type, treated in the burn unit. A review of clinical features and new therapeutics / Burns 40:e35~e39
Raison-Peyron N / 2013 / "Cutaneous adverse drug reactions"are not always drug-induced / Eur J Dermatol 23:439~442
Abbas M. / 2014 / Pustular psoriasis complicated with acute generalized exanthematous pustulosis / J Dermatol Case Rep 8:42~45
최민지 / 2010 / Clinicopathologic Manifestations of 36 Korean Patients with Acute Generalized Exanthematous Pustulosis: A Case Series and Review of the Literature / Annals of Dermatology 22(2):163~169
Varman KM. / 2014 / Acute generalized pustular psoriasis, von Zumbusch type, treated in the burn unit. A review of clinical features and new therapeutics / Burns 40:e35~e39
Raison-Peyron N / 2013 / "Cutaneous adverse drug reactions"are not always drug-induced / Eur J Dermatol 23:439~442
Abbas M. / 2014 / Pustular psoriasis complicated with acute generalized exanthematous pustulosis / J Dermatol Case Rep 8:42~45
최민지 / 2010 / Clinicopathologic Manifestations of 36 Korean Patients with Acute Generalized Exanthematous Pustulosis: A Case Series and Review of the Literature / Annals of Dermatology 22(2):163~169
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