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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 179 - 186 (8page)
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초록· 키워드
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Background: The adrenergic nervous system in the spinal cord contributes to the development of neuropathic pain after nerve injury. Brain derived neurotrophic factor may facilitate the sympathetic change in the spinal cord and influence the state of neuropathic pain. We probed the effect of chronic repetitive administration of systemic 4-methylcatechol, which is known to be a neurotrophic factor inducer, in a spinal nerve ligation model.
Methods: We made the rat neuropathic pain model by the ligation of the L5 spinal nerve. Intraperitoneal 4-methylcatechol (10μg/kg) or the same volume of saline wasadministrated twice daily just after the operation for 7 days. The tactile allodynia was measured by using von Frey filaments and its change was followed up from 3 days after SNL. The lumbosacral enlargement of the spinal cord was taken out and the mRNA contents of the α2-adrenoceptor subtypes were measured by real time polymerase chain reaction and this was then compared with the control groups. The antiallodynic effect of intrathecal clonidine (3, 10, 30μg) was evaluated and compared in the 4-methylcatechol treated rats and the control rats.
Results: The expression of the α2A and α2C adrenoceptor subtypes did not change after 4-methylcatechol treatment. Intrathecal clonidine showed an earlier and better effect at the highest dose (30μg intrathecal), but not with any other doses.
Conclusions: Chronic intraperitoneal administration of 4-methylcatechol may improve the effect of intrathecal clonidine, but we could not prove the increase of α2A and α2C adrenoceptors in the spinal cord of 4-methylcatechol treated rats. (Korean J Pain 2008; 21: 179-186)
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Callizot N / 2001 / Pyridoxine-induced neuropathy in rats: a sensory neuropathy that responds to 4-methylcatechol / Neurobiol Dis 8 : 626 ~ 35
Duflo F / 2003 / Spinal
Fukumitsu H / 1999 / Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol / Neuros
Gill HJ / 1988 / The celiac plexus block and the lumbar sympathetic ganglion block for the upper and lower abdominal cancer pain: 7 cases / Korean J Pain 1 : 171 ~ 6
Hanaoka Y / 1994 / The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats / J Neu
Duflo F / 2003 / Spinal
Fukumitsu H / 1999 / Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol / Neuros
Gill HJ / 1988 / The celiac plexus block and the lumbar sympathetic ganglion block for the upper and lower abdominal cancer pain: 7 cases / Korean J Pain 1 : 171 ~ 6
Hanaoka Y / 1994 / The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats / J Neu
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