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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 21 - 27 (7page)
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초록· 키워드
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Background: The neuropathic pain arising from nerve injury is difficult to treat and the therapeutic effects of opioid drugs remain debatable. Agonists acting at the α2 adrenergic and opioid receptors have analgesic properties and they act synergistically when co-administered in the spinal cord. The lack of subtype-selective pharmacological agents has previously impeded the synergistic effects that are mediated by the adrenergic receptor subtypes.
Methods: We created neuropathic pain model by ligating the L5 spinal nerve in Sprague-Dawley rats (n = 18). We divided the rats into three groups (n = 6 for each group), and we administered intraperitoneal morphine (1 ㎎/㎏, 3 ㎎/㎏, 5 ㎎/㎏) and then we measured the mechanical allodynia with using von-Frey filaments for 8 hours. We then injected morphine (5 ㎎/㎏) intraperitoneally, twice a day for 2 weeks. We measured the tactile and cold allodynia in the morphine group (n = 9) and the saline group (n = 9). After 2 weeks, we decapitated the rats and harvested the spinal cords at the level of lumbar enlargement. We compared the α2 subtype mRNA expression with that of control group (n = 6) by performing real time polymerase chain reaction (RTPCR).
Results: Intraperitoneal morphine reduced the neuropathic pain behavior in the dose-dependent manner. Chronic morphine administration showed an antiallodynic effect on the neuropathic pain rat model. The rats did not display tolerance or hyperalgesia. The expression of the mRNAs of the α2A, α2B, α2C subtypes decreased, and morphine attenuated this effect. But we could not get statistically proven results.
Conclusions: Systemic administration of morphine can attenuate allodynia during both the short-term and long-term time course. Morphine has an influence on the expression of α2 receptor subtype mRNA. Yet we need more research to determine the precise effect of morphine on the α2 subtype gene expression.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aantaa R / 1995 / Molecular pharmacology of alpha 2-adrenoceptor subtypes / Ann Med 27 : 439 ~ 449
Besse D / 1992 / Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: Comparison with scia
Bian D / 1995 / Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats / Neuroreport 6 : 1981 ~ 1984
Duflo F / 2002 / Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia / Anesthesiology 97 : 636 ~ 641
Goff JR / 1998 / Reorganization of the spinal dorsal horn in models of chronic pain: correlation with behaviour / Neuroscience 82 : 559 ~ 574
Besse D / 1992 / Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: Comparison with scia
Bian D / 1995 / Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats / Neuroreport 6 : 1981 ~ 1984
Duflo F / 2002 / Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia / Anesthesiology 97 : 636 ~ 641
Goff JR / 1998 / Reorganization of the spinal dorsal horn in models of chronic pain: correlation with behaviour / Neuroscience 82 : 559 ~ 574
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