지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 293 - 298 (6page)
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초록· 키워드
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Background: Chronic cough is a common non-specific symptom and has various causes including asthma.
Objective: The aims of this study were to compare eosinophilic degranulation in the airways between chronic cough patients with and without asthma and to evaluate correlations between sputum eosinophils and eosinophilic degranulation proteins.
Method: Thirty-seven patients with chronic cough and 9normal individuals (control group) were enrolled. Patients with chronic cough were divided into 2 groups based on positivity for bronchial hyperresponsiveness (BHR): those with asthma (asthma group, n=18) and those without asthma (non-asthma group, n=19). Sputum levels of eosinophilderived neurotoxin (EDN) and major basic protein (MBP)levels were measured, and eosinophil counts were performed in all patients.
Result: Sputum % eosinophils were increased in both the asthma and non-asthma groups compared to the control group. However, sputum EDN/MBP levels were increased only in the asthma group compared to the non-asthma and control groups. Sputum % eosinophils correlated positively with sputum EDN/MBP levels in the asthma group, but not in the Non-asthma group.
Conclusion: Increased EDN/MBP levels and significant correlations between % eosinophils and EDN/MBP levels were observed only in the asthma group, suggesting that eosinophil degranulation proteins could be a marker for identifying chronic cough due to asthma.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bousquet J / 1990 / Eosinophilic inflammation in asthma / N Engl J Med 323 : 1033 ~ 9
Brightling CE / 2000 / Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma / Am J Respir Crit Care Med 162 : 878 ~ 82
Fahy JV / 1993 / Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects / Am Rev Respir Dis 147 : 1126 ~ 31
Fujimoto K / 2003 / Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy / Respirology 8 : 168 ~
Fujimoto K / 2005 / Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease / Eur Respir J 25 : 640 ~ 6
Brightling CE / 2000 / Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma / Am J Respir Crit Care Med 162 : 878 ~ 82
Fahy JV / 1993 / Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects / Am Rev Respir Dis 147 : 1126 ~ 31
Fujimoto K / 2003 / Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy / Respirology 8 : 168 ~
Fujimoto K / 2005 / Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease / Eur Respir J 25 : 640 ~ 6
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