지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 83 - 91 (9page)
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Background: Fractional exhaled nitric oxide (FeNO) tests may detect eosinophilic airway inflammation in asthmatic patients and are known to be simple, easy and less time-consuming. However, there have been few studies on the usefulness of FeNO tests for the diagnosis and management of asthma in Korea. Methods: One hundred and sixty-one patients with asthma- like symptoms, such as episodic breathlessness, wheezing, cough and/or chest tightness, were included. Tests for FeNO and induced sputum were performed. Asthma was diagnosed if a subject had a positive airway hyperresponsiveness to methacholine or a significant reversible airflow obstruction. Levels of asthma control were classified according to the Expert Panel Report 3 guideline.
Results: The numbers of asthmatics and non-asthmatics were 90 and 71, respectively. FeNO levels positively correlated with sputum eosinophils. The area under the curve (AUC) from receiver operating characteristic curve of FeNO for asthma diagnosis was 0.686 (95% confidence interval [CI], 0.604∼0.767) and the optimal cutoff point was 25.5 ppb, which gave a sensitivity of 57.1%, a specificity of 75.7%, a positive predictive value (PPV) of 75.4% and a negative predictive value (NPV) of 57.6%. The AUC of FeNO for the determination of uncontrolled asthma was 0.812 (95% CI, 0.718∼0.906) and the optimal cutoff point was 24.5 ppb, which gave a sensitivity of 76.6%, a specificity of 80.8%, PPV of 90.7% and an NPV of 58.3%.
Conclusion: FeNO tests may be useful for diagnosing asthma and for assessing the level of asthma control, with good specificities and positive predictive values.
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참고문헌 (24)
참고문헌 신청
/ 1993 / Position paper: Allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology / Allergy 48 (14) : 48 ~ 82
American Thoracic Society / 2005 / ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and n
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Di
Delclaux C / 2002 / Increased nitric oxide output from alveolar origin during liver cirrhosis versus bronchial source during asthma / Am J Respir Crit Care Med 165 : 332 ~ 32
Douwes J / 2002 / Non-eosinophilic asthma: importance and possible mechanisms / Thorax 57 : 643 ~ 648
American Thoracic Society / 2005 / ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and n
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Di
Delclaux C / 2002 / Increased nitric oxide output from alveolar origin during liver cirrhosis versus bronchial source during asthma / Am J Respir Crit Care Med 165 : 332 ~ 32
Douwes J / 2002 / Non-eosinophilic asthma: importance and possible mechanisms / Thorax 57 : 643 ~ 648
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