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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 40 - 44 (5page)
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초록· 키워드
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Background: CD14 is found as a membrane-anchored molecule on the surface of monocytes, macrophages and granulocytes as well as in a soluble serum protein (sCD14) form. A single nucleotide polymorphism at position –159 in the promoter of CD14 has been shown to be associated with levels of sCD14 and total serum IgE. It has been believed that the polymorphism of the CD14 gene is associated with the atopic phenotype.
Objective: We attempted to determine whether –159C/T polymorphism in the promoter of CD14 is associated with Korean patients with atopic dermatitis (AD) and to assess its influence on their clinical subtypes.
Method: We performed polymerase chain reaction of the promoter of the CD14 gene on the genomic DNA from 346 Korean patients with AD and 116 non-AD controls using the restriction fragment-length polymorphism method. The serum levels of the total and specific IgE were measured by latex photometry immunoassay and enzyme-linked immunosorbent assay in patients with AD.
Result: No significant differences in the CD14 genotype frequencies were found between the groups. The polymorphism was associated with neither the total and specific IgE concentrations nor the generation of the different clinical subtypes of AD.
Conclusion: Our results suggest that the CD14 (C-159T) polymorphism may not be a major regulator in Korean patients with AD. (Korean J Asthma Allergy Clin Immunol 2008;28:40-44)
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참고문헌 (24)
참고문헌 신청
Baldini M / 1999 / A Polymorphism in the 5' flanking region of the CD14 gene is associated with circulating souluble CD14 levels and with total serum immunoglobulin E / Am J
Bu?kova D / 2003 / Two CD14 promotor polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy / Allergy 58 : 1023 ~ 1026
Gao PS / 1999 / Serum total IgE levels and CD14 on chromosome 5q31 / Clin Genet 56 : 164 ~ 165
Hanifin JM / 1980 / Diagnostic features of atopic dermatitis / Acta Derm Venereol 92 : 44 ~ 47
Hubacek JA / 1999 / T polymorphism in the promotor of the CD14 monocyte receptor gene as a risk factor for myocardial infraction / Circulation 99 : 3218 ~ 3220
Bu?kova D / 2003 / Two CD14 promotor polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy / Allergy 58 : 1023 ~ 1026
Gao PS / 1999 / Serum total IgE levels and CD14 on chromosome 5q31 / Clin Genet 56 : 164 ~ 165
Hanifin JM / 1980 / Diagnostic features of atopic dermatitis / Acta Derm Venereol 92 : 44 ~ 47
Hubacek JA / 1999 / T polymorphism in the promotor of the CD14 monocyte receptor gene as a risk factor for myocardial infraction / Circulation 99 : 3218 ~ 3220
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