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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 123 - 131 (9page)
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초록· 키워드
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Purpose: To investigate the effect of cilostazol on ocular hemodynamics and to determine whether the administrationof cilostazol increases the ocular blood flow in patients with diabetic retinopathy.
Methods: This prospective observational study investigated the effect of orally administered cilostazol on diabeticretinopathy. Before and after administration for 1 week, pulsatile ocular blood flow (POBF) and retrobulbarhemodynamics were measured using a POBF analyzer and transcranial Doppler imaging, respectively.
Visual acuity, intraocular pressure, and blood pressure were also evaluated before and after treatment.
Results: Twenty-five eyes of 25 patients were included in this study. POBF increased significantly (16.8 ± 4.6μL/sec vs. 19.6 ± 6.2 μL/sec, p < 0.001) after administration of cilostazol, while no significant change was identifiedin visual acuity, intraocular pressure, and blood pressure. Mean flow velocity in the ophthalmic artery asmeasured with transcranial Doppler imaging also increased significantly after medication (23.5 ± 5.6 cm/secvs. 26.0 ± 6.9 cm/sec, p = 0.001). The change in POBF directly correlated with the change in mean flow velocity(r = 0.419, p = 0.007).
Conclusions: Cilostazol was effective in increasing ocular blood flow in patients with diabetic retinopathy, possiblyby modulating retrobulbar circulation.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Patton N / 2005 / Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures / J Anat 206:319~348
Delaey C / 2000 / Regulatory mechanisms in the retinal and choroidal circulation / Ophthalmic Res 32:249~256
Li G / 2013 / MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension / Exp Eye Res 112:118~124
Yoshida Y / 2010 / A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma / J Ocul Pharmacol Ther 26:187~192
Uchiyama S / 2009 / Stroke prevention by cilostazol in patients with atherothrombosis:meta-analysis of placebo-controlled randomized trials / J Stroke Cerebrovasc Dis 18:482~490
Delaey C / 2000 / Regulatory mechanisms in the retinal and choroidal circulation / Ophthalmic Res 32:249~256
Li G / 2013 / MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension / Exp Eye Res 112:118~124
Yoshida Y / 2010 / A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma / J Ocul Pharmacol Ther 26:187~192
Uchiyama S / 2009 / Stroke prevention by cilostazol in patients with atherothrombosis:meta-analysis of placebo-controlled randomized trials / J Stroke Cerebrovasc Dis 18:482~490
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