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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study
Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제50권 제2호 KCI Accredited Journals SCOPUS
- 발행연도
- 2017.1
- 수록면
- 179 - 184 (6page)
이용수
Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study
초록· 키워드
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Background/Aims: Long-term use of aspirin can be a risk factor of peptic ulcer diseases. The aim of this study was to evaluate the efficacy of Albis (Daewoong Pharmaceutical Co., Ltd.) for the prevention of gastric mucosal injury caused by aspirin.
Methods: Aspirin users were enrolled and randomized into the Albis or placebo group. Screening and follow-up endoscopy were performed for modified Lanza scores (MLSs). Primary outcome was measured by the incidence rate of peptic ulcer, and secondary outcomes were measured by the incidence rate of gastritis, improvement in MLS and subjective symptoms.
Results: In total, 81 aspirin users were randomized, 43 in the Albis group and 38 in the placebo group. There was no incidence of peptic ulcer in both groups. The incidence of gastritis was significantly higher in the placebo group (44.4% vs. 10.0%, p=0.003); however, the scores of mucosal edema, hyperemia and hemorrhage were not statistically different between the two groups (p>0.05). The frequency of subjective symptoms were more improved in the Albis group than in the placebo group (p=0.023).
Conclusions: The incidence of gastritis was lower in the group that received low-dose aspirin and Albis. The development of peptic ulcer due to long-term use of aspirin might be prevented with concomitant use of Albis.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Cook D / 1998 / A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian critica
Ho PM / 2009 / Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome / JAMA 301 : 937 ~ 944
Lanas A / 2002 / Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin / Alime
Malfertheiner P / 2009 / Peptic ulcer disease / Lancet 374 : 1449 ~ 1461
Naito Y / 1998 / Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study / Dig Dis Sci 43 (
Ho PM / 2009 / Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome / JAMA 301 : 937 ~ 944
Lanas A / 2002 / Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin / Alime
Malfertheiner P / 2009 / Peptic ulcer disease / Lancet 374 : 1449 ~ 1461
Naito Y / 1998 / Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study / Dig Dis Sci 43 (
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