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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 11 (11page)
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Objective: Human papillomavirus (HPV) testing is widely incorporated into cervical cancer screening strategies. Current screening requires pelvic examination for cervical sampling, which may compromise participation. The acceptance could be raised by introducing testing on vaginal swabs. We explored the interchangeability of vaginal swabs and cervical smears for HPV testing, by means of a prospective study conducted in female sex workers (FSWs). Besides, we report on the occurrence of 32 different HPV genotypes in FSW with low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL). Methods: Paired physician-collected vaginal swabs and cervical smears from 303 FSW were tested for HPV using the Abbott RealTime High-Risk HPV assay. Cervical cytology was examined on cervical smears. In case of HSIL/LSIL cytological classification (n=52), both samples were genotyped using INNO-LiPa HPV Genotyping Extra II. Results: The overall prevalence of high-risk (HR)-HPV was 51%. In FSW with HSIL/LSIL cervical cytology, the sensitivity and specificity of vaginal samples for the detection of HR-HPV was 100% and 70% and for probable HR-HPV 100% and 91%. The mean number of genotypes identified in vaginal samples (mean=3.5; 95% confidence interval [CI]=2.8–4.2) was significantly higher than in cervical smear samples (mean=2.6; 95% CI=2.1–3.0) (p=0.001). The most frequently encountered HR-HPV genotypes were HPV16, 31, 51, and 52. Conclusion: As our study shows that vaginal swabs are equivalent to cervical smears for the detection of (probable) HR-HPV, vaginal swabs can be used for HPV testing in cervical cancer screening strategies. Given the acceptance of vaginal sampling, this finding offers an opportunity to boost screening coverage.
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참고문헌 (28)
참고문헌 신청
Taylor S / 2016 / The incidence, clearance and persistence of non-cervical human papillomavirus infections: a systematic review of the literature / BMC Infect Dis 16:293
Munoz N / 2003 / Epidemiologic classification of human papillomavirus types associated with cervical cancer / N Engl J Med 348:518~527
Lorincz A / 2013 / New strategies for human papillomavirus-based cervical screening / Womens Health (Lond) 9:443~452
Schwebke JR / 2011 / Molecular testing for Trichomonas vaginalis in women: results from a prospective U.S. clinical trial / J Clin Microbiol 49:4106~4111
Fang J / 2008 / Evaluation of self-collected vaginal swab, first void urine, and endocervical swab specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in adolescent females / J Pediatr Adolesc Gynecol 21:355~360
Munoz N / 2003 / Epidemiologic classification of human papillomavirus types associated with cervical cancer / N Engl J Med 348:518~527
Lorincz A / 2013 / New strategies for human papillomavirus-based cervical screening / Womens Health (Lond) 9:443~452
Schwebke JR / 2011 / Molecular testing for Trichomonas vaginalis in women: results from a prospective U.S. clinical trial / J Clin Microbiol 49:4106~4111
Fang J / 2008 / Evaluation of self-collected vaginal swab, first void urine, and endocervical swab specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in adolescent females / J Pediatr Adolesc Gynecol 21:355~360
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