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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 124 - 130 (7page)
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초록· 키워드
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In the present study, I investigated the effects of N-methyl-D-aspartate (NMDA), arachidonic acid (AA), and Nitric Oxide Synthase Inhibitor (NOSI), alone or in combination, on the proliferation of cultured primary normal human oral keratinocytes (NHOK). The purpose of this study was therefore the preliminary study for the examination of the interaction between these agents and NHOK in order to elucidate the mechanisms by which epithelial growth and regeneration are regulated. NHOK were obtained from gingival tissue of 20 individuals aged 20 to 29, and third passage (P3) cells were used for this study. The DNA synthesis was measured by the BrdU assay. Addition of low concentration of AA (1 μM) and high concentration of AA with NMDA group (NMDA+AA 10 μM) made DNA synthesis rate increase significantly at the early stage. Adding NNA (10 μM) affected DNA synthesis rate to increase significantly in 4 hours. At the early stage, DNA synthesis was significantly active in the NOS-I with NMDA groups than in the control and the NMDA-only group, while it didn’t become statistically meaningful in 24 hours. AA 1 μM and NNA 10 μM may induce the proliferation of the NHOK independently and NOS-I may induce the proliferation of the NHOK with NMDA. These reactions might be related to the NMDA receptor in the cell and the change of the intracellular calcium ion concentration.
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참고문헌 (27)
참고문헌 신청
/ / Barrier function regulates epidermal DNA synthesis : 1668 ~ 73
/ / Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes : 409 ~ 414
/ / NMDAevoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells 115 : 723 ~ 729
/ 1996 / Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation 107 : 412 ~ 418
/ 1996 / Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures 112 : 219 ~ 226
/ / Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes : 409 ~ 414
/ / NMDAevoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells 115 : 723 ~ 729
/ 1996 / Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation 107 : 412 ~ 418
/ 1996 / Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures 112 : 219 ~ 226
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