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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 109 - 115 (7page)
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초록· 키워드
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Background:The pathophysiological and neurochemical changes following spinal injury are not yet elucidated. This study was designed to evaluate the morphological changes of the dorsal horn of the spinal cord and profiles of pain behaviors following intraspinal injection of NMDA in rats.
Methods:Rats were randomized into three groups: a sham-operated control group and groups where the rats received 10 mM or 100 mM N-methyl-D-aspatate (NMDA) injected into their spinal dorsal horn. Following injection, hypersensitivity to cold and mechanical stimuli and excessive grooming behaviors were assessed serially for four weeks. Morphological changes of the spinal cord were evaluated four weeks after intraspinal injection.
Results:Few animals in the NMDA groups developed hypersensitivity to cold and mechanical stimuli. The number of groomers and the severity of excessive grooming were significantly higher in the 100 mM NMDA group than those values of the control and 10 mM NMDA groups. The size of the neck region (lamina III-IV) was significantly smaller in the 100 mM NMDA group than in the control and 10 mM NMDA groups.
Conclusions:In conclusion, intraspinal injection of NMDA in rats leads to the pathological sequela in the spinal cord and to excessive grooming behavior. These results support the use of NMDA and excessive grooming behavior after excitotoxic SCI as a model to study chronic pain after SCI. (Korean J Pain 2010; 23: 109-115)
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Brewer KL / 2008 / Dermatomal scratching after intramedullary quisqualate injection: correlation with cutaneous denervation / J Pain 9 : 999 ~ 1005
Bruce JC / 2002 / Chronic pain after clip-compression injury of the rat spinal cord / Exp Neurol 178 : 33 ~ 48
Choi DW / 1992 / Excitotoxic cell death / J Neurobiol 23 : 1261 ~ 1276
Gomes-Leal W / 2004 / Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury / Exp Neurol 190 : 456 ~ 467
Gorman AL / 2001 / Conditions affecting the onset, severity, and progression of a spontaneous pain-like behavior after excitotoxic spinal cord injury / J Pain 2 : 229 ~ 240
Bruce JC / 2002 / Chronic pain after clip-compression injury of the rat spinal cord / Exp Neurol 178 : 33 ~ 48
Choi DW / 1992 / Excitotoxic cell death / J Neurobiol 23 : 1261 ~ 1276
Gomes-Leal W / 2004 / Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury / Exp Neurol 190 : 456 ~ 467
Gorman AL / 2001 / Conditions affecting the onset, severity, and progression of a spontaneous pain-like behavior after excitotoxic spinal cord injury / J Pain 2 : 229 ~ 240
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