지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제22권 제1호
- 발행연도
- 1999.1
- 수록면
- 35 - 43 (9page)
이용수
초록· 키워드
오류제보하기
Overstimulation of both kainate (KA) and N-methyl-D-aspartate (NMDA) receptors has been reported to induce excitatoxicity which can be characterized by neuronal damage and formation of reactive oxygen free radicals. Neuroprotective effect of melatonin against KA-induced excitotoxicity have been documented in vitro and in vivo. It is, however, not clear whether melationin is also neuroportective against excitotoxicity mediated by NMDA receptors. In the present work, we tested the in vivo protective effects of striatally infused melatonin against the oxidative stress and neuronal damage induced by the injection of KA and NMDA receptors into the rat striatum. Melatonin implants consisting of 22-gauge stainless-steel cannule with melatonin fused inside the tip were placed bilaterally in the rat brain one week prior to intrastriatal injection of glutamate receptor subtype agonists. Melatonin showed protective effects against the elevation of lipid peroxidation induced by either KA or NMDA and recovered Cu, Zn-superoxide dismutase activities reduced by both KA and NMDA into the control level. Melatonin also clearly blocked both KA- and NMDA-receptor mediated neuronal damage assessed by the determination of choline acetyltransferase activity in striatal monogenages and by microscopic observation of rat brain section stained with cresyl violet. The protective effects of melatonin are comparable to those of DNQX and MK801 which are the KA- and NMDA-receptor antagonist, respectively. It is suggested that melatonin could protect against striatal oxidative damages mediated by glutamate receptors, both non-NMDA and NMDA receptors.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
일차 배양 해마신경세포에서 NMDA- 및 Glutamate- 유도전류의 특성
대한신경외과학회지
2000 .01
-
NMDA receptor dysfunction in mouse models of autism
대한소아청소년정신의학회 학술대회논문집
2018 .11
-
Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Development of New NMDA Receptor Agonists/Antagonists
대한약학회 학술대회
2003 .01
-
NMDA Receptor and NO Mediate ET-1-Induced Behavioral and Cardiovascular Effects in Periaqueductal Gray Matter of Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
-
NMDA Receptor Antagonists Enhance 5-HT2 Receptor-Mediated Behavior, Head-Twitch Response, in PCPA-Treated Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Ginsenosides Inhibit NMDA Receptor-Mediated Epileptic Discharges in Cultured Hippocampal Neurons
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
NONCOMPETITIVE NMDA RECEPTOR ANTAGONISTS INHIBIT APOMORPHINE-INDUCED CLIMBING BEHAVIOR IN RESERPINE-TREATED MICE
한국응용약물학회 춘계학술발표논문집
1996 .01
-
GABAA Receptor- and Non-NMDA Glutamate Receptor-Mediated Actions of Korean Red Ginseng Extract on the Gonadotropin Releasing Hormone Neurons
Journal of Ginseng Research
2012 .01
-
멜라토닌과 정신분열증
생물치료정신의학
1997 .12
-
Possible involvement of NMDA receptors in Toluene-induced depression-like behavior in adult mice
한국실험동물학회 학술발표대회 논문집
2010 .08
-
The NMDA Receptor Hypofunction Hypothesis for Schizophrenia and Glycine Modulatory Sites on the NMDA Receptors as Potential Therapeutic Drugs
Clinical Psychopharmacology and Neuroscience
2006 .01
-
Synthesis of 7,8-Dichloro-6-Nitro-1H-1,5-Benzodiazephine-2,4-(3H, 5H)-dione as a potential NMDA Receptor Glycine Site Antagonist
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
Central Pain from Excitotoxic Spinal Cord Injury Induced by Intraspinal NMDA Injection: A Pilot Study
The Korean Journal of Pain
2010 .01
-
A Case of Anti-NMDA Receptor Encephalitis with Normal Findings on Initial Diagnostic Tests
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
-
원지(遠志)가 NMDA로 유발된 선경세포 손상에 미치는 효과
대한본초학회지(본초분과학회지)
2005 .01
-
Participation of NMDA and non-NMDA glutamate receptors in the formalin-induced inflammatory temporomandibular joint nociception
International Journal of Oral Biology
2007 .01
-
메틸수은으로 손상된 골모세포에 대한 NMDA 수용체길항제의 영향
동의생리병리학회지
2003 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0