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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 2010.1
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Purpose: Chemokines are structurally related, small polypeptide signaling molecules that bind to and activate a family of transmembrane G proteincoupled receptors, the chemokine receptors. Recently, interaction between the chemokine receptor CXCR4 and its ligand, stromal cell-derived factor 1(SDF-1 or CXCL12), has been found to play an important role in tumorigenicity, proliferation, metastasis and angiogenesis in many cancers such as lung cancer, breast cancer, melanoma, glioblastoma, pancreatic cancer and cholangiocarcinoma.
Hence, the goal of this study is to identify the correlation of clinicopathological factors and the up-regulation of SDF-1 expression in oral squamous cell carcinoma.
Material and methods: We studied the immunohistochemical staining of SDF-1, quantitative RT-PCR (qRT-PCR) of SDF-1 gene in 20 specimens of 20 patients with oral squamous cell carcinoma.
Results: 1. In the immunohistochemical study of poor differentiated and invasive oral squamous cell carcinoma, the high level staining of SDF-1was observed. And the correlation between immunohistochemical SDF-1 expression and tumor nodes metastases (TNM) classification of specimens was significant.(x2 test, P < 0.05)2. In the SDF-1 gene qRT-PCR analysis, SDF-1 expression was more in tumor tissue than in carcinoma in situ tissue. Paired-samples analysis determined the difference of SDF-1 mRNA expression level between the cancer tissue and the carcinoma in situ tissue.(Student’s t-test, P < 0.05)Conclusion: These findings suggest that up-regulation of the SDF-1 may play a role in progression and invasion of oral squamous cell carcinoma.
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참고문헌 (26)
참고문헌 신청
Bertolini F / 2002 / CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin’s lymphoma / Cancer Res 62 : 3106 ~ 3112
Carvalho AL / 2003 / Sites of recurrence in oral and oropharyngeal cancers according to the treatment approach / Oral Dis 9 : 112 ~ 118
Carvalho AL / 2004 / Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution / Oral Oncol 40 : 71 ~ 76
Daly AJ / 2008 / Regulation of HGF and SDF- 1 expression by oral fibroblasts-implications for invasion of oral cancer / Oral Oncol 44 : 646 ~ 651
Fernandez EJ / 2002 / Structure, function, and inhibition of chemokines / Annu Rev Pharmacol Toxicol 42 : 469 ~ 499
Carvalho AL / 2003 / Sites of recurrence in oral and oropharyngeal cancers according to the treatment approach / Oral Dis 9 : 112 ~ 118
Carvalho AL / 2004 / Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution / Oral Oncol 40 : 71 ~ 76
Daly AJ / 2008 / Regulation of HGF and SDF- 1 expression by oral fibroblasts-implications for invasion of oral cancer / Oral Oncol 44 : 646 ~ 651
Fernandez EJ / 2002 / Structure, function, and inhibition of chemokines / Annu Rev Pharmacol Toxicol 42 : 469 ~ 499
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