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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제9호
- 발행연도
- 2018.1
- 수록면
- 1,443 - 1,446 (4page)
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초록· 키워드
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In the present study, we examined whether Lactobacillus johnsonii CJLJ103 (LJ) could alleviate cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamineinduced memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-α expression and NF-κB activation. LJ also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit acetylcholinesterase activity. These findings suggest that LJ, a member of human gut microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and inhibiting NF-κB activation.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Britton GB / 2011 / Cognitive aging and early diagnosis challenges in Alzheimer's disease / J. Alzheimers Dis. 24(Suppl 2):153~159
Araujo JA / 2005 / Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging / Prog. Neuropsychopharmacol. Biol. Psychiatry 29:411~422
Jung K / 2009 / Mangiferin ameliorates scopolamine-induced learning deficits in mice / Biol. Pharm. Bull. 32:242~246
Jang YJ / 2013 / Decaffeinated coffee prevents scopolamine-induced memory impairment in rats / Behav. Brain Res. 245:113~119
Lu B / 2014 / BDNF and synaptic plasticity, cognitive function, and dysfunction / Handb. Exp. Pharmacol. 220:223~250
Araujo JA / 2005 / Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging / Prog. Neuropsychopharmacol. Biol. Psychiatry 29:411~422
Jung K / 2009 / Mangiferin ameliorates scopolamine-induced learning deficits in mice / Biol. Pharm. Bull. 32:242~246
Jang YJ / 2013 / Decaffeinated coffee prevents scopolamine-induced memory impairment in rats / Behav. Brain Res. 245:113~119
Lu B / 2014 / BDNF and synaptic plasticity, cognitive function, and dysfunction / Handb. Exp. Pharmacol. 220:223~250
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