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Improvement Effect of Stachys sieboldii MIQ. According to Mixing Ratio of Calcium on Memory Impairment in Scopolamine-induced Dementia Rats
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칼슘 배합 비율에 따른 초석잠의 scopolamine 치매유도 흰쥐에 대한 기억손상 개선 효과

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Type
Academic journal
Author
Da-Jeong Choe (동아대학교) Hee-Young Ahn (동아대학교) Young-Wan Kim (동아대학교) Tae-Hoon Kim (동아대학교) Man-do Kim (지에스피) Young-Su Cho (동아대학교)
Journal
Korean Society Of Life Science Journal of Life Science Vol.26 No.7 KCI Accredited Journals
Published
2016.7
Pages
812 - 818 (7page)

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Improvement Effect of Stachys sieboldii MIQ. According to Mixing Ratio of Calcium on Memory Impairment in Scopolamine-induced Dementia Rats
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Research history (2)

2017

최다정 생명공 2017.01 Thesis

2016

Improvement Effect of Stachys sieboldii MIQ. According to Mixing Ratio of Calcium on Memory Impairment in Scopolamine-induced Dementia Rats
Da-Jeong Choe ,  Hee-Young Ahn ,  Young-Wan Kim and others 3 Journal of Life Science 2016.07 Academic journal
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Abstract· Keywords

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The aim of this study was to investigate the anti-amnesic effect of Stachys sieboldii MIQ. according to the mixing ratio of calcium on scopolamine-induced learning and memory impairment, in vivo. At the end of the adaptation period, SD rats were divided into a normal group (N), a control group (C: scopolamine), a positive control group (PC: scopolamine + tacrine), and a sample group (S: scopolamine + Stachys sieboldii MIQ., 1CS: scopolamine + low calcium-mixed Stachys sieboldii MIQ., 5CS: scopolamine + high calcium-mixed Stachys sieboldii MIQ.), and were tested with learning and memory tests. The C and CS groups were found to have a decreased scopolamine-induced memory deficit in the Y-maze and water maze tests. Brain tissue analysis showed that the CS group decreased acetylcholinesterase (AChE) activity and increased acetylcholine (Ach) content, both of which are indicative of neuronal cell activity. From a light microscopy study, the nucleus of neurons in the hippocampus of the brain was more shrunken or condensed in the C group compared to the CS group. In the CS group, the damage to the neurons in the hippocampus of the brain was suppressed. These results suggest that Stachys sieboldii MIQ. according to the mixing ratio of calcium provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.
#Acetylcholine #acetylcholinesterase #dementia #scopolamine #Stachys sieboldii MIQ.

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재료 및 방법
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References (28)

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[학술지(정기간행물)] - 배동혁 / 2014 / Scopolamine으로 유도된 기억력 손상 동물모델에서 비파엽 추출물의 학습 및 기억력 개선 효과 / 한국식품영양과학회지 43 (6) : 799 ~ 806 dbpia [학술지(정기간행물)] - Bartus, R. T. / 1982 / The cholinergic hypothesis of geriatric memory dysfunction / Science 217 : 408 ~ 414 google schola [학술지(정기간행물)] - Jae-Young Cha / 2004 / Prevention of Orotic Acid-induced Fatty Liver in Rats by Capsaicin / Food Science and Biotechnology 13 (5) : 597 ~ 602 dbpia [학술지(정기간행물)] - Colye, J. T. / 1983 / Alzheimer’s disease: a disorder of cortical cholinergic innervation / Science 219 : 1184 ~ 1190 google schola [학술지(정기간행물)] - Davises, P. / 1976 / Selective loss of central cholinergic neurons in Alzheimer’s disease / Lancet 2 : 1403 ~ google schola

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UCI(KEPA) : I410-ECN-0101-2017-470-001029760