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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 1 - 8 (8page)
- DOI
- 10.17495/easdl.2017.2.27.1.1
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초록· 키워드
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This study was conducted to investigate alterations of seaweed composition upon Lactobacillus rhamnosus GG (LGG) fermentation as well as potential anti-inflammatory effects and mechanism (s) of water extracts and fermented water extracts of Laminaria japonica (LJ) and Hizikia fusiforme (HF) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Total polyphenol, total sugar, and reducing sugar contents were measured in LJ and HF water extracts before and after fermentation by LGG. Alterations of inflammatory cytokine levels in cell culture media were measured by ELISA, and levels of phosphorylation of c-jun NH2-terminalkinase (JNK) and extra cellular signal regulated kinase (ERK) were examined by Western blot analysis. LGG fermentation of LJ and HF altered total polyphenol and sugar contents in water extracts of LJ and HF. LPS-induced production of pro-inflammatory cytokines such as IL-6 and TNF-α was significantly reduced by HF-f compared to control in RAW264.7 cells. Consistent with reduction of anti-inflammatory cytokine, interleukin (IL)-6, and tumor necrosis factor (TNF)-α levels by HF-f, HF-f also significantly reduced phosphorylation of ERK and JNK in LPS-stimulated RAW264.7 cells. In addition, LJ-f and HF also significantly reduced phosphorylation of JNK and ERK induced by LPS in RAW264.7 cells. Overall, our result suggests that HF-f among the four tested seaweed extracts is the most potent antiinflammatory agent, and its mechanism of action is partially mediated by reduction of JNK and ERK phosphorylation as well as IL-6 and TNF-α production in LPS-stimulated RAW264.7 cells.
목차
ABSTRACT
서론
연구 방법
결과 및 고찰
요약 및 결론
REFERENCES
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - Anisowicz A / 1991 / An NF- Kappa B-like transcription factor mediates IL-1/TNF-alpha induction of Gro in human fibroblasts / J Immunol 147 : 520 ~ 527
[학술지(정기간행물)] - 배향남 / 2010 / Improvement of the Functional Qualities of Sea Tangle Extract through Fermentation by Aspergillus oryzae / Fisheries and Aquatic Sciences 13 (1) : 12 ~ 17
[학술지(정기간행물)] - Baker RG / 2011 / NF-κB, inflamma- tion, and metabolic disease / Cell Met 13 : 11 ~ 22
[학술지(정기간행물)] - Chandini SK / 2008 / In vitro antioxi-dant activities of three selected brown seaweeds of India / Food Chem 107 : 707 ~ 713
[학술지(정기간행물)] - Chen I / 2009 / Lactic fermentation and antioxidant activity of Zingiberaceae plants in Taiwan / Int J Food Sci Nutr 60 : 57 ~ 66
[학술지(정기간행물)] - 배향남 / 2010 / Improvement of the Functional Qualities of Sea Tangle Extract through Fermentation by Aspergillus oryzae / Fisheries and Aquatic Sciences 13 (1) : 12 ~ 17
[학술지(정기간행물)] - Baker RG / 2011 / NF-κB, inflamma- tion, and metabolic disease / Cell Met 13 : 11 ~ 22
[학술지(정기간행물)] - Chandini SK / 2008 / In vitro antioxi-dant activities of three selected brown seaweeds of India / Food Chem 107 : 707 ~ 713
[학술지(정기간행물)] - Chen I / 2009 / Lactic fermentation and antioxidant activity of Zingiberaceae plants in Taiwan / Int J Food Sci Nutr 60 : 57 ~ 66
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UCI(KEPA) : I410-ECN-0101-2017-594-002325440