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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제3호
- 발행연도
- 2018.1
- 수록면
- 491 - 497 (7page)
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Lipopolysaccharide (LPS), a component of the cell wall of gram-negative bacteria, elicits the secretion of cytokines, such as interferons, that stimulate the host defense system. Previously, we demonstrated that interferons induce interferon regulatory factors (IRFs) 1, 3, and 7, which regulate the transcription of Noxa and alter the expression profiles of Bcl-2 family proteins in tumors. However, the immediate consequences of LPS stimulation on Noxa and BH3 expression in tumor cells remain uncharacterized. In this study, we determined that LPS induced Noxa expression in CT26 cells. Furthermore, studies in HCT116 parental and HCT116 p53-deficient cells revealed that LPS-mediated Noxa was independent of p53. Meanwhile, IRF1, 3, and 7 in CT26, HCT116 parental, and HT116 p53-deficient cells were upregulated by LPS stimulation, suggesting that LPS induces the expression of these IRFs in a p53- independent manner. The responsiveness of IRF1, 3, 4, and 7 binding to the Noxa promoter region to LPS indicated that IRF1, 3, and 7 activated Noxa expression, whereas IRF4 repressed Noxa expression. Together, these results suggest that LPS directly affects Noxa expression in tumor cells through IRFs, implicating that it may contribute to LPS-induced tumor regression.
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참고문헌 (45)
참고문헌 신청
Freudenberg MA / 2008 / Lipopolysaccharide sensing an important factor in the innate immune response to gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity / Immunobiology 213:193~203
Won EK / 2003 / Analysis of the antitumoral mechanisms of lipopolysaccharide against glioblastoma multiforme / Anticancer Drugs 14:457~466
Chicoine MR / 2001 / Intratumoral injection of lipopolysaccharide causes regression of subcutaneously implanted mouse glioblastoma multiforme / Neurosurgery 48:607~614
Inagawa H / 1998 / Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions / Anticancer Res. 18:3957~3964
Goto S / 1996 / Intradermal administration of lipopolysaccharide in treatment of human cancer / Cancer Immunol. Immunother. 42:255~261
Won EK / 2003 / Analysis of the antitumoral mechanisms of lipopolysaccharide against glioblastoma multiforme / Anticancer Drugs 14:457~466
Chicoine MR / 2001 / Intratumoral injection of lipopolysaccharide causes regression of subcutaneously implanted mouse glioblastoma multiforme / Neurosurgery 48:607~614
Inagawa H / 1998 / Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions / Anticancer Res. 18:3957~3964
Goto S / 1996 / Intradermal administration of lipopolysaccharide in treatment of human cancer / Cancer Immunol. Immunother. 42:255~261
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