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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제3호
- 발행연도
- 2017.1
- 수록면
- 439 - 449 (11page)
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초록· 키워드
오류제보하기
Beauveria bassiana infects a number of pest species and is known to produce insecticidal substances, such as the nonribosomal peptides (NRPs) beauvericin and bassianolide. However, most NRPs and their biological roles in B. bassiana remain undiscovered. To identify NRPs that potentially contribute to pathogenesis, the 21 predicted NRP synthetases (NRPSs) or NRPS-like proteins of B. bassiana ARSEF 2860 were primarily ranked into three functional groups: basic metabolism (7 NRPSs), pathogenicity (12 NRPSs), and unknown function (2 NRPSs). Based on the transcript levels during in vivo growth on diamondback moth (Plutella xylostella (Linnaeus)), half of the Group II NRPSs were likely to be involved in infection. Given that the metabolites biosynthesized by these NRPSs remain to be determined, our result underlines the importance of the NRPSome in fungal pathogenesis, and will serve as a guide for future genomic mining projects to discover functionally essential and structurally diverse NRPs in fungal genomes.
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참고문헌 (24)
참고문헌 신청
Boettger D / 2013 / Molecular diversity sculpted by fungal PKS-NRPS hybrids / Chembiochem 14 : 28 ~ 42
Bolker M / 2008 / Ustilago maydis secondary metabolism - from genomics to biochemistry / Fungal Genet. Biol 45 : S88 ~ S93
Chiang Y-M / 2008 / Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway / Chem. Biol 15 : 527 ~ 532
Collemare J / 2014 / Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum / PLoS One 9 : e85877 ~
Du LC / 2010 / PKS and NRPS release mechanisms / Nat. Prod. Rep 27 : 255 ~ 278
Bolker M / 2008 / Ustilago maydis secondary metabolism - from genomics to biochemistry / Fungal Genet. Biol 45 : S88 ~ S93
Chiang Y-M / 2008 / Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway / Chem. Biol 15 : 527 ~ 532
Collemare J / 2014 / Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum / PLoS One 9 : e85877 ~
Du LC / 2010 / PKS and NRPS release mechanisms / Nat. Prod. Rep 27 : 255 ~ 278
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