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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제11호
- 발행연도
- 2017.1
- 수록면
- 2,060 - 2,069 (10page)
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초록· 키워드
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Newcastle disease is a serious infectious disease in the poultry industry. The commercial vaccines can only offer limited protection and some of them are expensive and need adjuvants.
At present, DNA vaccines are widely used. However, the immune responses induced by DNA vaccines are too slow and low. Here, we constructed the transfer vectors with a different number of C3d as molecular adjuvants (n = 1, 2, 4, or 6), and the vectors were cloned into the optimal eukaryotic expression plasmid (pVAXI-optiF) that expressed the F gene of Newcastle disease virus (NDV), and named pVAXI-F(o)-C3d1, pVAXI -F(o)-C3d2, pVAXI-F(o)-C3d4, and pVAXI-F(o)-C3d6, respectively. Cell transfection test indicated that pVAXI-F(o)-C3d6 showed the highest expression. In vivo immunization showed that the chickens immunized with pVAXI-F(o)-C3d6 intramuscularly induced better immune responses than the chickens immunized with the other plasmids. The protective efficacy of pVAXI-F(o)-C3d6 was 80% after challenge with the highly virulent NDV strain F48E9. The results in this study showed that C3d6 could be used as a molecular adjuvant to quickly induce an effective immune response to control NDV.
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참고문헌 (23)
참고문헌 신청
Baxter D. / 2007 / Active and passive immunity, vaccine types, excipients and licensing / Occup. Med 57 : 552 ~ 556
Cardenas-Garcia S / 2015 / Development of an improved vaccine evaluation protocol to compare the efficacy of Newcastle disease vaccines / Biologicals 43 : 136 ~ 145
Cardenas-Garcia S / 2016 / Effects of chicken interferon gamma on Newcastle disease virus vaccine immunogenicity / PLoS One 11 : e0159153 ~
Crepeaux G / 2017 / Nonlinear dose-response of aluminium hydroxide adjuvant particles: selective low dose neurotoxicity / Toxicology
DiNapoli JM / 2009 / Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans / Vacci
Cardenas-Garcia S / 2015 / Development of an improved vaccine evaluation protocol to compare the efficacy of Newcastle disease vaccines / Biologicals 43 : 136 ~ 145
Cardenas-Garcia S / 2016 / Effects of chicken interferon gamma on Newcastle disease virus vaccine immunogenicity / PLoS One 11 : e0159153 ~
Crepeaux G / 2017 / Nonlinear dose-response of aluminium hydroxide adjuvant particles: selective low dose neurotoxicity / Toxicology
DiNapoli JM / 2009 / Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans / Vacci
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