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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제2호
- 발행연도
- 2009.1
- 수록면
- 136 - 139 (4page)
이용수
초록· 키워드
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Avermectin and its analogs are major commercial antiparasitic
agents in the fields of animal health, agriculture, and
human infections. Previously, comparative transcriptome
analysis between the low-producer S. avermitilis ATCC31267
and the high-producer S. avermitilis ATCC31780 using a
S. avermitilis whole genome chip revealed that 50 genes
were overexpressed at least two-fold higher in S. avermitilis
ATCC31780. To verify the biological significance of some
of the transcriptomics-guided targets, five putative regulatory
genes were individually cloned under the strong-andconstitutive
promoter of the Streptomyces expression vector
pSE34, followed by the transformation into the lowproducer
S. avermitilis ATCC31267. Among the putative
genes tested, three regulatory genes including SAV213,
SAV3818, and SAV4023 exhibited stimulatory effects on
avermectin production in S. avermitilis ATCC31267. Moreover,
overexpression of SAV3818 also stimulated actinorhodin
production in both S. coelicolor M145 and S. lividans
TK21, implying that the SAV3818, a putative TetR-family
transcriptional regulator, could be a global upregulator
acting in antibiotic production in Streptomyces species.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Albers-Schoenberg, G. / 1981 / Avermectins. Structure determination / J. Am. Chem. Soc 103 : 4216 ~ 4221
Beck, C. F. / 1982 / A multifunctional gene (tetR) controls Tn10-encoded tetracycline resistance / J. Bacteriol 150 : 633 ~ 642
Burg, R. W. / 1979 / Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation / Antimicrob. Agents Chemother 15 : 361 ~ 367
Croft, S. L. / 1997 / The current status of antiparasite chemotherapy / Parasitology 114 : 83 ~ 96
Demain, A. L. / 1999 / Pharmaceutically active secondary metabolites of microorganisms / Appl. Microbiol. Biotechnol 52 : 455 ~ 463
Beck, C. F. / 1982 / A multifunctional gene (tetR) controls Tn10-encoded tetracycline resistance / J. Bacteriol 150 : 633 ~ 642
Burg, R. W. / 1979 / Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation / Antimicrob. Agents Chemother 15 : 361 ~ 367
Croft, S. L. / 1997 / The current status of antiparasite chemotherapy / Parasitology 114 : 83 ~ 96
Demain, A. L. / 1999 / Pharmaceutically active secondary metabolites of microorganisms / Appl. Microbiol. Biotechnol 52 : 455 ~ 463
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