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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제3호
- 발행연도
- 2007.1
- 수록면
- 534 - 538 (5page)
이용수
초록· 키워드
오류제보하기
Avermectin and its analogs are major comercialand human infections. To increase our understanding aboutthe genetic mechanism underlying avermectin overproduction,comparative transcriptomes were analyzed between the lowproducer S. avermitilis ATC31267 and the high producer S.avermitilis ATCC31780 via a S. avermitilis whole genomechip. The comparative transcriptome analysis revealed thatfifty S. avermitilis genes were expressed at least two-foldhigher in ATCC31780. In particular, al theavermectin biosynthetic genes, including polyketide synthase(PKS) genes and an avermectin pathway-specific regulatorygene, were les expresed in the low producer S. avermitilisATCC31267. The present results imply that avermectinoverproduction in S. avermitilis ATCC31780 could be attributedto the previously unidentified fifty genes reported here andincreased transcription levels of avermectin PKS genes.
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참고문헌 (17)
참고문헌 신청
Burg / 1979 / new family of potent anthelmintic agents; producing organism and fermentation : 361 ~ 367
Hillerich, B / 2006 / A new GntR family transcriptional regulator in Streptomyces coelicolor is required for morphogenesis and antibiotic production and controls transcriptio
Huang, J / 2001 / Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathway in Streptomyces coelicolor using DNA microarray
Hwang, E. I / 2005 / Compound IKD- 8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp 15 : 909 ~ 912
Hwang, Y. S / 2003 / Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains 69 : 1263 ~ 1269
Hillerich, B / 2006 / A new GntR family transcriptional regulator in Streptomyces coelicolor is required for morphogenesis and antibiotic production and controls transcriptio
Huang, J / 2001 / Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathway in Streptomyces coelicolor using DNA microarray
Hwang, E. I / 2005 / Compound IKD- 8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp 15 : 909 ~ 912
Hwang, Y. S / 2003 / Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains 69 : 1263 ~ 1269
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