지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제10호
- 발행연도
- 2008.1
- 수록면
- 1,655 - 1,658 (4page)
이용수
초록· 키워드
오류제보하기
Cyanobacteria, blue-green algae, are a rich source of
bioactive secondary metabolites with many potential
applications. The ubiquitin-proteasome proteolytic system
plays an important role in selective protein degradation
and regulates cellular events including apoptosis. Cancer
cells are more sensitive to the proapoptotic effects of
proteasome inhibition than normal cells. Thus, proteasome
inhibitors can be potential anticancer agents. Cyanobacteria
have been shown to be a rich source of highly effective
inhibitors of proteases. A proteasome inhibitor was screened
from an extract of the culture of Scytonema hofmanni on
the basis of its inhibitory activity, which led to the
isolation of nostodione A with an IC50 value of 50 μM. Its
structure was determined by spectroscopic methods such
as 1H-NMR and ESI-MS spectral analyses.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
AGRAWAL, MANISH K. / 2006 / Occurrence of Microcystin-Containing Toxic Water Blooms in Central India / Journal of Microbiology and Biotechnology 16 (2) : 212 ~ 218
Adams, J. / 2004 / The proteasome: A suitable antineoplastic target / Nat. Rev 4 : 349 ~ 460
Beasly, V. R. / 2000 / Microcystin-LR decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly d
Bonjouklian, R. / 1996 / A90720A, a serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis / Tetrahedron 52 : 385 ~ 404
Clardy, J. / 2004 / Lessons from natural molecules / Nature 432 : 829 ~ 837
Adams, J. / 2004 / The proteasome: A suitable antineoplastic target / Nat. Rev 4 : 349 ~ 460
Beasly, V. R. / 2000 / Microcystin-LR decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly d
Bonjouklian, R. / 1996 / A90720A, a serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis / Tetrahedron 52 : 385 ~ 404
Clardy, J. / 2004 / Lessons from natural molecules / Nature 432 : 829 ~ 837
함께 읽어보면 좋을 논문
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Developmental Regulation of Proteolytic Activities of Proteasome in Chick Embryonic Myoblasts in Culture
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1996 .01
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Proteasome Inhibitor MG-132 Induces Apoptosis in Human Acute Leukemia Jurkat T Cells through Mitochondria-Dependent Caspase Pathway That is Negatively Modulated in the Presence of Caspase-12 Inhibitor (z-ATAD-fmk) or Caspase-4 Inhibitor (z-LEVD-fmk)
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2008 .10
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Induced Degradation of Tat by NC via the Proteasome Pathway and Its Effect on HIV Transcription
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Isolation and Molecular Characterization of Proteasome $\alpha$-Subunit Gene in Petunia Hybrida
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RPN10, and Subunit Interaction Maps of 265 Proteasome and Cop9 Complexes
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Primary Structures of Two Homologous Subunits of PA28, a $\gamma$-interferon-inducible Protein Activator of the 20S Proteasome
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In Situ Identification of Cyanobacteria
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2001 .11
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CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6' subunits of 26S proteasome
Animal cells and systems
2010 .01
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SIRT1 Suppresses Activating Transcription Factor 4 (ATF4) Expression in Response to Proteasome Inhibition
Journal of Microbiology and Biotechnology
2013 .01
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Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets
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봄철 Cyanobacteria가 우점한 천호지에서 세균군집구조의 변화
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2002 .12
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PERCEPTION OF LIGHT BY CYANOBACTERIA DURING CHROMATIC ADAPTATION
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Ubiquitin E3 ligases controlling p53 stability
Animal cells and systems
2012 .01
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Screening and Isolation of Chymotrypsin Inhibitors
한국동물학회 학술대회
1995 .01
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Protein and RNA Quality Control by Autophagy in Plant Cells
Molecules and Cells
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