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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 173 - 182 (10page)
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The p53 protein plays a pivotal role in tumor suppression. The cellular level of p53 is normally kept low by proteasome-mediated degradation, allowing cell cycle progression and cell proliferation. Under stress conditions, such as DNA damage, p53 is stabilized and activated through various post-translational modifications of itself as well as of its regulatory proteins for induction of the downstream genes responsible for cell cycle arrest, DNA repair, and apoptosis. Therefore, the level of p53 should be tightly regulated for normal cell growth and for prevention of the accumulation of mutations in DNA under stress conditions, which otherwise would lead to tumorigenesis. Since the discovery of Mdm2, a critical ubiquitin E3 ligase that destabilizes p53 in mammalian cells, nearly 20 different E3 ligases have been identified and shown to function in the control of stability, nuclear export, translocation to chromatin or nuclear foci, and oligomerization of p53. So far, a large number of excellent reviews have been published on the control of p53 function in various aspects. Therefore, this review will focus only on mammalian ubiquitin E3 ligases that mediate proteasome-dependent degradation of p53.
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참고문헌 (116)
참고문헌 신청
Adhikary S / 2005 / The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation / Cell 123:409~421
Amano T / 2003 / Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy / Genes Dev 17:2436~2449
Anderson CW / 2010 / Signaling to the p53 tumor suppressor through pathways activated by genotoxic and non-genotoxic stresses, In Handbook of cell signaling. 2nd ed / Academic Press :2185~2204
Ashcroft M / 2000 / Stress signals utilize multiple pathways to stabilize p53 / Mol Cell Biol 20:3224~3233
Baert JL. / 2010 / The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity / Oncogene 29:1810~1820
Amano T / 2003 / Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy / Genes Dev 17:2436~2449
Anderson CW / 2010 / Signaling to the p53 tumor suppressor through pathways activated by genotoxic and non-genotoxic stresses, In Handbook of cell signaling. 2nd ed / Academic Press :2185~2204
Ashcroft M / 2000 / Stress signals utilize multiple pathways to stabilize p53 / Mol Cell Biol 20:3224~3233
Baert JL. / 2010 / The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity / Oncogene 29:1810~1820
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