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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제3호
- 발행연도
- 2016.1
- 수록면
- 579 - 587 (9page)
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초록· 키워드
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Mastitis is a prevalent inflammatory disease that remains one of the main causes of poor quality of milk. Phytoncides are naturally occurring anti-inflammatory compounds derived from plants and trees. To determine if treatment with phytoncide could decrease the severity of lipopolysaccharide (LPS)-induced inflammatory responses, mammary alveolar epithelial cells (MAC-T) were pretreated with phytoncide (0.02% and 0.04% (v/v)) followed by LPS treatment (1 and 25 μg/ml). The results demonstrated that phytoncide downregulated LPSinduced pro-inflammatory cyclooxygenase-2 (COX-2) expression. Additionally, LPS-induced activation of ERK1/2, p38, and Akt was attenuated by phytoncide. Treatment of cells with known pharmacological inhibitors of ERK1/2 (PD98059), p38 (SB203580), and Akt (LY294002) confirmed the association of these signaling pathways with the observed alterations in COX-2 expression. Moreover, phytoncide attenuated LPS-induced NF-κB activation and superoxide production, and, finally, treatment with phytoncide increased Nrf2 activation. Results suggest that phytoncide can decrease LPS-induced inflammation in MAC-T cells.
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참고문헌 (37)
참고문헌 신청
Akira S / 2003 / Mammalian Toll-like receptors / Curr. Opin. Immunol 15:5~11
Bradley A. / 2002 / Bovine mastitis: an evolving disease / Vet. J 164:116~128
Chandrasekharan NV / 2004 / The cyclooxygenases / Genome Biol 5:241
De UK / 2014 / Activity of cyclooxygenase-2and nitric oxide in milk leucocytes following intramammary inoculation of a bio-response modifier during bovine Staphylococcus aureus subclinical mastitis / Vet. Res. Commun 38:201~207
Fujimori H / 2009 / Protecting effect of phytoncide solution on normal human dermal fibroblasts against reactive oxygen species / J. Oleo Sci 58:429~436
Bradley A. / 2002 / Bovine mastitis: an evolving disease / Vet. J 164:116~128
Chandrasekharan NV / 2004 / The cyclooxygenases / Genome Biol 5:241
De UK / 2014 / Activity of cyclooxygenase-2and nitric oxide in milk leucocytes following intramammary inoculation of a bio-response modifier during bovine Staphylococcus aureus subclinical mastitis / Vet. Res. Commun 38:201~207
Fujimori H / 2009 / Protecting effect of phytoncide solution on normal human dermal fibroblasts against reactive oxygen species / J. Oleo Sci 58:429~436
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