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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제10호
- 발행연도
- 2017.1
- 수록면
- 1,892 - 1,895 (4page)
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IK can downregulate interferon-gamma-induced major histocompatibility complex (MHC) class II expression through the MHC class II transactivator, which suggests that IK can inhibit the interactions between immune cells. We delivered adeno-associated virus serotype 2 (AAV2) encoding the genes for truncated IK (tIK) or green fluorescent protein (GFP) to DBA1/J mice via intravenous injection. Seven weeks after injection, collagen-induced arthritis was induced in the AAV2-treated mice. AAV2-tIK injection reduced the severity of arthritis and the percentage of pathogenic Th17 cells compared with AAV2-GFP injection. These results suggest a novel gene therapy strategy for treatment of inflammatory arthritis.
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참고문헌 (17)
참고문헌 신청
Assier E / 1999 / Isolation, sequencing and expression of RED, a novel human gene encoding an acidic?basic dipeptide repeat / Gene 230 : 145 ~ 154
Brand DD / 2007 / Collageninduced arthritis / Nat. Protoc 2 : 1269 ~ 1275
Daya S / 2008 / Gene therapy using adenoassociated virus vectors / Clin. Microbiol. Rev 16 : 1073 ~ 1080
Hernandez-Pando R / 1997 / The role of TNF-a in T-cell-mediated inflammation depends on the Th1/Th2cytokine balance / Immunology 82 : 591 ~ 595
Kotterman MA / 2014 / Engineering adenoassociated viruses for clinical gene therapy / Nat. Rev. Gene 15 : 445 ~ 451
Brand DD / 2007 / Collageninduced arthritis / Nat. Protoc 2 : 1269 ~ 1275
Daya S / 2008 / Gene therapy using adenoassociated virus vectors / Clin. Microbiol. Rev 16 : 1073 ~ 1080
Hernandez-Pando R / 1997 / The role of TNF-a in T-cell-mediated inflammation depends on the Th1/Th2cytokine balance / Immunology 82 : 591 ~ 595
Kotterman MA / 2014 / Engineering adenoassociated viruses for clinical gene therapy / Nat. Rev. Gene 15 : 445 ~ 451
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