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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제2호
- 발행연도
- 2017.1
- 수록면
- 380 - 387 (8page)
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초록· 키워드
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The foamy viruses are currently considered essential for development as vectors for gene delivery. Previous studies demonstrated that prototype foamy virus (PFV) can infect and replicate prevalently in a variety of cell types for its exclusive replication strategy. However, the virus-host interaction, especially PFV-transportin3 (TNPO3), is still poorly understood. In our investigation of the role of TNPO3 in PFV infection, we found lower virus production in TNPO3 knockdown (KD) cells compared with wild-type 293T cells. PCR analysis revealed that viral DNAs were mostly altered to circular forms: both 1-long terminal repeat (1-LTR) and 2-LTR in TNPO3 KD cells. We therefore suggest that TNPO3 is required for successful PFV replication, at least at/after the nuclear entry step of viral DNA. These findings highlight the obscure mysteries of PFV-host interaction and the requirement of TNPO3 for productive infection of PFV in 293T cells.
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참고문헌 (25)
참고문헌 신청
Achong BG / 1971 / An unusual virus in cultures from a human nasopharyngeal carcinoma / J. Natl. Cancer Inst 46 : 299 ~ 307
Ali MK / 2015 / Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection / Biosci. Biotechnol. Biochem 9 : 1 ~ 9
Armand-Ugon M / 2003 / HIV-1 resistance to the gp41-dependen
Bodem J / 1996 / Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses / J.
Brass AL / 2008 / Identification of host proteins required for HIV infection through a functional genomic screen / Science 319 : 921 ~ 926
Ali MK / 2015 / Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection / Biosci. Biotechnol. Biochem 9 : 1 ~ 9
Armand-Ugon M / 2003 / HIV-1 resistance to the gp41-dependen
Bodem J / 1996 / Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses / J.
Brass AL / 2008 / Identification of host proteins required for HIV infection through a functional genomic screen / Science 319 : 921 ~ 926
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