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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제9호
- 발행연도
- 2020.1
- 수록면
- 1,273 - 1,281 (9page)
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초록· 키워드
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Due to the broad host suitability of viral vectors and their high gene delivery capacity, many researchers are focusing on viral vector-mediated gene therapy. Among the retroviruses, foamy viruses have been considered potential gene therapy vectors because of their non-pathogenicity. To date, the prototype foamy virus is the only retrovirus that has a high-resolution structure of intasomes, nucleoprotein complexes formed by integrase, and viral DNA. The integration of viral DNA into the host chromosome is an essential step for viral vector development. This process is mediated by virally encoded integrase, which catalyzes unique chemical reactions. Additionally, recent studies on foamy virus integrase elucidated the catalytic functions of its three distinct domains and their effect on viral pathogenicity. This review focuses on recent advancements in biochemical, structural, and functional studies of foamy virus integrase for gene therapy vector research.
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참고문헌 (128)
참고문헌 신청
Busch H / 1972 / Genetic engineering and cancer chemotherapy / Oncology 26:152~179
Goff SP / 1976 / Construction of hybrid viruses containing SV40 and l phage DNA segments and their propagation in cultured monkey cells / Cell 9:695~705
Cepko CL / 1984 / Construction and applications of a highly transmissible murine retrovirus shuttle vector / Cell 37:1053~1062
Rosenberg SA / 1990 / Gene transfer into humans—immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction / N. Engl. J. Med 323:570~578
The Journal of Gene Medicine / Gene Therapy Clinical Trials Worldwide Database
Goff SP / 1976 / Construction of hybrid viruses containing SV40 and l phage DNA segments and their propagation in cultured monkey cells / Cell 9:695~705
Cepko CL / 1984 / Construction and applications of a highly transmissible murine retrovirus shuttle vector / Cell 37:1053~1062
Rosenberg SA / 1990 / Gene transfer into humans—immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction / N. Engl. J. Med 323:570~578
The Journal of Gene Medicine / Gene Therapy Clinical Trials Worldwide Database
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