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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제11호
- 발행연도
- 2016.1
- 수록면
- 1,836 - 1,844 (9page)
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Adipogenesis is one of the cellular processes and a highly controlled program. Nowadays, inhibition of adipogenesis has received attention as an effective way to regulate obesity. In the current study, we investigated the inhibition effect of a chloroform extract of Pleurotus eryngii var. ferulae ‘Beesan No. 2’ (CEBT) on adipogenesis in 3T3-L1 murine preadipocytes. Pleurotus eryngii var. ferulae is one of many varieties of King oyster mushroom and has been reported to have various biological activities, including antitumor and anti-inflammation effects.Biological activities of ‘Beesan No. 2’, a new cultivar of Pleurotus eryngii var. ferulae, have not yet been reported. In this study, we found that CEBT suppressed adipogenesis in 3T3-L1 cells through inhibition of key adipogenic transcription factors, such as peroxisome proliferatoractivated receptor γ and CCAAT/enhancer binding protein α. Additionally, CEBT reduced the expression of the IRS/PI3K/Akt signaling pathway and its downstream factors, including mammalian target of rapamycin and p70S6 kinase, which stimulate adipogenesis.
Furthermore, β-catenin, a suppressor of adipogenesis, was increased in CEBT-treated cells. These results indicate that Pleurotus eryngii var. ferulae ‘Beesan No. 2’ effectively inhibited adipogenesis, so this mushroom has potential as an anti-obesity food and drug.
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참고문헌 (16)
참고문헌 신청
Ali AT / 2013 / Adipocyte and adipogenesis / Eur. J. Cell Biol 92 : 229 ~ 236
Bray GA / 2004 / Medical consequences of obesity / J. Clin. Endocrinol. Metab 89 : 2583 ~ 2589
Camp HS / 2002 / Adipogenesis and fat-cell function in obesity and diabetes / Trends Mol. Med 8 : 442 ~ 447
Chirala SS / 2004 / Structure and function of animal fatty acid synthase / Lipids 39 : 1045 ~ 1053
Cross DA / 1995 / Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B / Nature 378 : 785 ~ 789
Bray GA / 2004 / Medical consequences of obesity / J. Clin. Endocrinol. Metab 89 : 2583 ~ 2589
Camp HS / 2002 / Adipogenesis and fat-cell function in obesity and diabetes / Trends Mol. Med 8 : 442 ~ 447
Chirala SS / 2004 / Structure and function of animal fatty acid synthase / Lipids 39 : 1045 ~ 1053
Cross DA / 1995 / Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B / Nature 378 : 785 ~ 789
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