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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 27 - 34 (8page)
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C/EBPβ and C/EBPδ are required for the initiation of adipogenesis and induce the expression of key adipogenic regulators, such as PPARγ and C/EBPα. In the present study, we have examined the effects of silibinin and its possible molecular mechanisms in regulating adipocyte differentiation and expression of C/ EBPβ and C/EBPδ in the early stage of adipogenesis. Silibinin statistically significantly inhibits intracellular lipid accumulation and the mRNA expression of various genes involved at different stages during adipogenesis. Silibinin also suppresses expression of lipoprotein lipase (LPL), fatty acid binding protein 4 (AP2), and adiponectin in 3T3-L1 adipocytes. Thus, the anti-adipogenic effect of silibinin seems to originate from the ability to inhibit the expression of C/EBPβ and C/EBPδ. Furthermore, silibinin decreases cell viability for differentiation period and induces apoptotic cell death through capspase-3 activation.
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참고문헌 (23)
참고문헌 신청
Cristofalo R / 2013 / Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women / Free Radical Res 47 : 268 ~ 275
Dhanalakshmi S / 2002 / Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced
Hishida T / 2009 / The role of C/EBPdelta in the early stages of adipogenesis / Biochimie 91 : 654 ~ 657
Ka SO / 2009 / Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway / Int. J. Molecul. Med 23 : 633 ~ 637
Katiyar SK / 2005 / Silymarin and skin cancer prevention: antiinflammatory, antioxidant and immunomodulatory effects (Review) / Int. J. Oncol 26 : 169 ~ 176
Dhanalakshmi S / 2002 / Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced
Hishida T / 2009 / The role of C/EBPdelta in the early stages of adipogenesis / Biochimie 91 : 654 ~ 657
Ka SO / 2009 / Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway / Int. J. Molecul. Med 23 : 633 ~ 637
Katiyar SK / 2005 / Silymarin and skin cancer prevention: antiinflammatory, antioxidant and immunomodulatory effects (Review) / Int. J. Oncol 26 : 169 ~ 176
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Reactive Oxygen Species Depletion by Silibinin Stimulates Apoptosis- Like Death in Escherichia coli
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Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells
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Inhibitory effect of ethanolic extract of Abeliophyllum distichum leaf on 3T3-L1 adipocyte differentiation
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Anti-adipogenic Effect and Mechanism in 3T3-L1 Preadipocytes by Cyclosporin A, an Immunosuppressant
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Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
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Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
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Acer okamotoanum Nakai Leaf Extract Inhibits Adipogenesis Via Suppressing Expression of PPAR γ and C/EBP α in 3T3-L1 Cells
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Propyl Gallate Inhibits Adipogenesis by Stimulating Extracellular Signal-Related Kinases in Human Adipose Tissue-Derived Mesenchymal Stem Cells
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Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
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Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
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Inhibitory Effects and Molecular Mechanism of Adipocyte Differentiation by Rosae laevigata Fructus Ethanol Extracs
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Histone H3 Lysine Methylation in Adipogenesis
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팔각회향 dichloromethane 분획물에 의한 지방세포 분화 억제 효과
생명과학회지
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바위수염 메탄올 추출물이 3T3-L1 지방전구세포의 분화에 미치는 영향
생명과학회지
2015 .01
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The micosporine-like amino acids-rich aqueous methanol extract of laver (Porphyra yezoensis) inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes
Nutrition Research and Practice
2015 .12
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The micosporine-like amino acids-rich aqueous methanol extract of laver (Porphyra yezoensis) inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes
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Elephant Garlic Extracts Inhibit Adipogenesis in 3T3-L1 Adipocytes
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2020 .01
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3T3-L1 세포에서 상엽이 유발하는 AMPK signaling pathway를 통한 adipogenesis 억제에 관한 연구
생명과학회지
2017 .02
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Psidium guajava L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cells
Nutrition Research and Practice
2021 .10
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