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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제10호
- 발행연도
- 2009.1
- 수록면
- 1,103 - 1,108 (6page)
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초록· 키워드
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The human immunodeficiency virus (HIV)-1 protein Tat
acts as a transcription transactivator that stimulates
expression of the infected viral genome. It is released from
infected cells and can similarly affect neighboring cells.
The nucleocapsid is an important protein that has a
related significant role in early mRNA expression, and
which contributes to the rapid viral replication that occurs
during HIV-1 infection. To investigate the interaction
between the Tat and nucleocapsid proteins, we utilized
cDNA microarrays using pTat and flag NC cotransfection
in HEK 293T cells and reverse transcription-polymerase
chain reaction to validate the microarray data. Four
upregulated genes and nine downregulated genes were
selected as candidate genes. Gene ontology analysis was
conducted to define the biological process of the input genes.
A proteomic approach using PathwayStudio determined the
relationship between Tat and nucleocapsid; two automatically
built pathways represented the interactions between the
upregulated and downregulated genes. The results indicate
that the up- and downregulated genes regulate HIV-1
replication and proliferation, and viral entry.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Albini, A. / 1996 / The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells / Nat. Med 2 : 1371 ~ 1375
Bacharach, E. / 2000 / The carboxy-terminal fragment of nucleolin interacts with the nucleocapsid domain of retroviral Gag proteins and inhibits virion assembly / J. Virol 74
Belka, C. / 2003 / The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways / Oncogene 22 : 176 ~ 185
Bettaccini, A. A. / 2005 / Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: Expression profile of pathogenetically relevant genes / BMC Mi
Biswas, D. K. / 1995 / A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter / J. Virol 69 : 7437 ~ 7444
Bacharach, E. / 2000 / The carboxy-terminal fragment of nucleolin interacts with the nucleocapsid domain of retroviral Gag proteins and inhibits virion assembly / J. Virol 74
Belka, C. / 2003 / The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways / Oncogene 22 : 176 ~ 185
Bettaccini, A. A. / 2005 / Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: Expression profile of pathogenetically relevant genes / BMC Mi
Biswas, D. K. / 1995 / A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter / J. Virol 69 : 7437 ~ 7444
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Expression Profiles and Pathway Analysis in HEK 293 T Cells OverexpressingHIV-1 Tat and Nucleocapsid Using cDNA Microarray
Journal of Microbiology and Biotechnology
2007 .01
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Interaction Between Nucleocapsid and Tat protein of Human Immunodeficiency Virus Type 1 (HIV-1) and Its Effect on Tat-mediated Transcription
한국미생물학회 학술대회논문집
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Human Immunodeficiency Virus-1 Tat 단백에 의한 인간 CD99 유전자의 조절기전에 대한 연구
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2008 .12
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Human Immunodeficiency Virus Type 1 Tat-Mediated Cellular Response in Myeloid Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2014 .03
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HIV-1 Tat Protein Promotes Amyloid β Generation and Tau Phosphorylation in Rat Hippocampal Slices
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2014 .03
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Up-regulation of Galectin-3 in HIV-1 tat-transfected Cells
생명과학회지
2005 .04
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Characteristics of HIV-Tat Protein Transduction Domain
The Journal of Microbiology
2004 .12
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Degradation of Tat by NC via the Proteasome Pathway and Its Effect on HIV Transcription
한국미생물학회 학술대회논문집
2012 .05
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Induced Degradation of Tat by NC via the Proteasome Pathway and Its Effect on HIV Transcription
한국미생물학회 학술대회논문집
2013 .05
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Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes
Experimental and Molecular Medicine
2009 .01
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프마이크로어레이 데이터의 유전자 집합 및 대사 경로 분석
유전체소식
2006 .01
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HIV-1 Latency and AIDS Pathogenesis in Association with p53 and HIV-1 Tat
한국미생물학회 학술대회논문집
2006 .05
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A Possible Innate Cellular Defense System against Viral Infection : PKR-Independent Translational Inhibition in Infected Cells by HIV-1 Tat Protein
한국미생물학회 학술대회논문집
2004 .05
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Exploiting Drug Repositioning for Discovery of Novel Compounds Inhibiting HIV-1 Tat-mediated Viral Transcription
한국미생물학회 학술대회논문집
2019 .04
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Production of the Nucleocapsid Protein of Newcastle Disease Virus in Escherichia coli and its Assembly into Ring- and Nucleocapsid-like Particles
The Journal of Microbiology
2001 .12
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High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription
Experimental and Molecular Medicine
2016 .01
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Statistical Analysis of Gene Expression Data
한국생물정보시스템생물학회 워크샵
2001 .01
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Extracellular HIV-1 Tat enhances monocyte adhesion byup-regulation of ICAM-1 and VCAM-1 gene expression viaROS-dependent NF-κB activation in astrocytes
Experimental and Molecular Medicine
2007 .01
-
HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices : Involvement of the ERK1/2 Signaling Pathway
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .03
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Effects of Mumps Virus Nucleocapsid Protein on the Viral Replication and Apoptosis in VeroE6 Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2003 .09
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