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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제1호
- 발행연도
- 2007.1
- 수록면
- 154 - 161 (8page)
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초록· 키워드
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Human imunodeficiency virus type 1 (HIV-1)infections are responsible for a substantial number of deathsannually and represent a significant threat to public health.protein is essential in transcription and replication of viralgenes, and is among the early expresion genes involved inthe life cycle of HIV. The virion NC (nucleocapsid) plays animportant role in early mRNA expression and contributes tothe rapid viral replication that ocurs during HIV-1 infection.Therefore, we attempted to elucidate the relationship betweenthe Tat protein and nucleocapsid protein. In a comparison oftwo independently prepared and hybridized samples, flag NC293T cells, and hybridization showed the differences inexpression in each case. Among the microarray results confirmedwith real-time reverse transcriptase assay, twelve genes wereidentified to be involved according to their gene expressionprofiles. Of approximately 8,208 human genes that wereanalyzed, we monitored candidate genes that might have beenrelated to NC and Tat genes from gene expresion profiles.Additionally, the pathways could be viewed and analyzedthrough the use of PathwayStudio software. The pathwaysmolecules/cell objects/processes by the curation method.
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참고문헌 (23)
참고문헌 신청
A / 1989 / Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1 : 5781 ~ 86 5785
Accola, M. A / 2000 / Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a
Barillari / 1993 / and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation : 277 ~ 287
Brigati, C / 2003 / HIV Tat, its TARgets and the control of viral gene expression 220 : 57 ~ 65
Clemens, M. J / 2000 / Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells 7 : 603 ~ 615
Accola, M. A / 2000 / Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a
Barillari / 1993 / and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation : 277 ~ 287
Brigati, C / 2003 / HIV Tat, its TARgets and the control of viral gene expression 220 : 57 ~ 65
Clemens, M. J / 2000 / Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells 7 : 603 ~ 615
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