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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,457 - 1,460 (4page)
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초록· 키워드
오류제보하기
Seven flavonoids were isolated from Spatholobus suberectus via repetitive column chromatography and high-performance liquid chromatography. The chemical structures of these compounds were identified by spectroscopic analysis and comparison with values reported in the literature. Among the flavonoids tested, 7-hydroxy-6-methoxyflavanone (1) and formononetin (4) exhibited strong inhibitory activity against Streptococcus mutans SrtA, with IC50 values of 46.1 and 41.8 μM, respectively, but did not affect cell viability. The onset and magnitude of inhibition of saliva-induced aggregation in S. mutans treated with compounds 1 and 4 were comparable to the behavior of a srtA-deletion mutant without treatment.
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참고문헌 (20)
참고문헌 신청
Abreu Matos FJ / 1975 / Flavonoids from Dalbergia ecastophyllum / Phytochemistry 14 : 825 ~ 826
Bevan CWL / 1966 / West African timbers. Part XIII. Extracts from the heartwood of Amphimas pterocarpoides and Pterocarpus erinacesus / J. Chem. Soc. C 1966 : 509 ~ 510
Bradbury RB / 1951 / The chemistry of subterranean clover. Part I. Isolation of formononetin and genistein / J. Chem. Soc 1951 : 3447 ~ 3449
Braga de Oliveira A / 1972 / Flavonoids and coumarins from Platymiscium praecox / Phytochemistry 11 : 3515 ~ 3519
Clancy KW / 2010 / Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition / Biopolymers 94 : 385 ~ 396
Bevan CWL / 1966 / West African timbers. Part XIII. Extracts from the heartwood of Amphimas pterocarpoides and Pterocarpus erinacesus / J. Chem. Soc. C 1966 : 509 ~ 510
Bradbury RB / 1951 / The chemistry of subterranean clover. Part I. Isolation of formononetin and genistein / J. Chem. Soc 1951 : 3447 ~ 3449
Braga de Oliveira A / 1972 / Flavonoids and coumarins from Platymiscium praecox / Phytochemistry 11 : 3515 ~ 3519
Clancy KW / 2010 / Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition / Biopolymers 94 : 385 ~ 396
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