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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제9호
- 발행연도
- 2015.1
- 수록면
- 1,425 - 1,428 (4page)
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Monoamine oxidase (MAO) is found in most cell types and catalyzes the oxidation of monoamines. Three anithiactins (A-C, modified 2-phenylthiazoles) isolated from Streptomyces sp. were tested for inhibitory activity of two isoforms, MAO-A and MAO-B. Anithiactin A was effective and selective for the inhibition of MAO-A, with an IC50 value of 13.0 μM; however, it was not effective for the inhibition of MAO-B. Anithiactins B and C were weaker inhibitors for MAO-A and MAO-B. Anithiactin A was a reversible and competitive inhibitor for MAO-A with a Ki value of 1.84 μM. The hydrophobic methyl substituent in anithiactin A may play an important role in the inhibition of MAO-A. It is suggested that anithiactin A is a selective reversible inhibitor for MAO-A, with moderate potency, and can be considered a new potential lead compound for further development of novel reversible inhibitors for MAO-A.
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참고문헌 (23)
참고문헌 신청
Abdelhafez OM / 2012 / Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors / J. Med. Chem 55 : 10424 ~ 10436
Bautista-Aguilera OM / 2014 / N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine
Berlin I / 1990 / Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and ass
Callebert J / 2006 / Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine (2B) receptors in mice / J. Pharmacol. Exp. Ther 317 : 724 ~ 731
Doly S / 2008 / Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro / J. Neurosci 28 :
Bautista-Aguilera OM / 2014 / N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine
Berlin I / 1990 / Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and ass
Callebert J / 2006 / Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine (2B) receptors in mice / J. Pharmacol. Exp. Ther 317 : 724 ~ 731
Doly S / 2008 / Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro / J. Neurosci 28 :
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