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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제2호
- 발행연도
- 2017.1
- 수록면
- 316 - 320 (5page)
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초록· 키워드
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Alternariol monomethyl ether (AME), a dibenzopyrone derivative, was isolated from Alternaria brassicae along with altertoxin II (ATX-II). The compounds were tested for the inhibitory activity of monoamine oxidase (MAO), which catalyzes neurotransmitting monoamines. AME was found to be a highly potent and selective inhibitor of human MAO-A with an IC50 value of 1.71 μM; however, it was found to be ineffective for MAO-B inhibition. ATX-II was not effective for the inhibition of either MAO-A or MAO-B. The inhibition of MAO-A using AME was apparently instantaneous. MAO-A activity was almost completely recovered after the dilution of the inhibited enzyme with an excess amount of AME, suggesting AME is a reversible inhibitor. AME showed mixed inhibition for MAO-A in Lineweaver-Burk plots with a Ki value of 0.34 μM. The findings of this study suggest that microbial metabolites and dibenzopyrone could be potent MAO inhibitors. In addition, AME could be a useful lead compound for developing reversible MAO-A inhibitors to treat depression, Parkinson’s disease, and Alzheimer’s disease.
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참고문헌 (24)
참고문헌 신청
Abdelhafez OM / 2012 / Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors / J. Med. Chem 55 : 10424 ~ 10436
Berlin I / 1990 / Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and as
Carradori S / 2014 / Selective MAO-B inhibitors: a lesson from natural products / Mol. Divers 18 : 219 ~ 243
Dolle F / 2003 / Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A / Bioorg. M
Fowler JS / 2010 / Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAOA by CX157 / Neuropsychopharmacology 35 : 623 ~ 631
Berlin I / 1990 / Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and as
Carradori S / 2014 / Selective MAO-B inhibitors: a lesson from natural products / Mol. Divers 18 : 219 ~ 243
Dolle F / 2003 / Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A / Bioorg. M
Fowler JS / 2010 / Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAOA by CX157 / Neuropsychopharmacology 35 : 623 ~ 631
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