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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제12호
- 발행연도
- 2009.1
- 수록면
- 1,582 - 1,589 (8page)
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Bacterial UDP-N-acetylglucosamine enolpyruvyl transferase
(MurA) catalyzes the transfer of enolpyruvate from
phosphoenolpyruvate (PEP) to uridine diphospho-Nacetylglucosamine
(UNAG), which is the first step of
bacterial cell wall synthesis. We identified thimerosal,
thiram, and ebselen as effective inhibitors of Haemophilus
influenzae MurA by screening a chemical library that
consisted of a wide range of bioactive compounds. When
MurA was preincubated with these inhibitors, their 50%
inhibitory concentrations (IC50s) were found to range
from 0.1 to 0.7 μM. In particular, thimerosal suppressed
the growth of several different Gram-negative bacteria such
as Escherichia coli, Pseudomonas aeruginosa, and Salmonella
typhimurium at a concentration range of 1-2 μg/ml. These
inhibitors covalently modified the cysteine residue near
the active site of MurA. This modification changed the
open conformation of MurA to a more closed configuration,
which may have prevented the necessary conformational
change from occurring during the enzyme reaction.
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참고문헌 (21)
참고문헌 신청
Arca, P. / 1997 / Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicenter survey / J. Antimicrob. Chemother 40 : 393 ~ 399
Barbosa, M. D. / 2002 / Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors / Antimicrob. Agents Chemother 46 : 943 ~ 946
Baskin, D. S. / 2003 / Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts / Toxicol. Sci 74 : 361
Baum, E. Z. / 2001 / Identification and characterization of a new inhibitor of the Escherichia coli MurA enzyme / Antimicrob. Agents Chemother 45 : 3182 ~ 3188
Bernat, B. A. / 1997 / Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases / Biochemistr
Barbosa, M. D. / 2002 / Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors / Antimicrob. Agents Chemother 46 : 943 ~ 946
Baskin, D. S. / 2003 / Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts / Toxicol. Sci 74 : 361
Baum, E. Z. / 2001 / Identification and characterization of a new inhibitor of the Escherichia coli MurA enzyme / Antimicrob. Agents Chemother 45 : 3182 ~ 3188
Bernat, B. A. / 1997 / Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases / Biochemistr
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