지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제7호
- 발행연도
- 2008.1
- 수록면
- 1,326 - 1,334 (9page)
이용수
초록· 키워드
오류제보하기
The prime-boost vaccination with DNA vaccine and
recombinant viral vector has emerged as an effective
prophylactic strategy to control infectious diseases. Here,
we compared the protective immunities induced by
multiple alternating immunizations with DNA vaccine
(pCIgB) and replication-incompetent adenovirus (Ad-gB)
expressing glycoprotein gB of pseudorabies virus (PrV).
The platform of pCIgB-prime and Ad-gB-boost induced
the most effective immune responses and provided protection
against virulent PrV infection. However, priming with
pCIgB prior to vaccinating animals by the DNA vaccineprime
and Ad-boost protocol provided neither effective
immune responses nor protection against PrV. Similarly,
boosting with Ad-gB following immunization with DNA
vaccine-prime and Ad-boost showed no significant responses.
Moreover, whereas the administration of Ad-gB for primary
immunization induced Th2-type-biased immunity, priming
with pCIgB induced Th1-type-biased immunity, as judged
by the production of PrV-specific IgG isotypes and cytokine
IFN-γ. These results indicate that the order and injection
frequency of vaccine vehicles used for heterologous primeboost
vaccination affect the magnitude and nature of the
immunity. Therefore, our demonstration implies that the
prime-boost protocol should be carefully considered and
selected to induce the desired immune responses.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Amara, R. R. / 2002 / Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/ MVA vaccine / Vaccine 20 : 1949 ~ 1955
Barouch, D. H. / 2005 / Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum / Gene Ther 16 : 149 ~ 156
Bianchi, A. T. / 1998 / A mouse model to study immunity against Pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~
Casimiro, D. R. / 2004 / Heterologous human immunodeficiencyvirus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vacc
Dory, D. / 2005 / Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC,
Barouch, D. H. / 2005 / Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum / Gene Ther 16 : 149 ~ 156
Bianchi, A. T. / 1998 / A mouse model to study immunity against Pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~
Casimiro, D. R. / 2004 / Heterologous human immunodeficiencyvirus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vacc
Dory, D. / 2005 / Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC,
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective Immunity Induced by Systemic and Mucosal Delivery of DNAVaccine Expressing Glycoprotein B of Pseudorabies Virus
Journal of Microbiology and Biotechnology
2008 .01
-
CD8⁺ T 세포 특이 Epitope 발현 Recombinant Vaccinia Virus와 DNA Vaccine을 이용한 Prime-boost 접종법에 의하여 유도되는 in vivo CTL Activity
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2007 .03
-
Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus
Experimental and Molecular Medicine
2008 .01
-
Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with β2-adrenergic agonist
Experimental and Molecular Medicine
2009 .01
-
Immunogenicity of a DNA and Recombinant Protein Vaccine Combining LipL32 and Loa22 for Leptospirosis Using Chitosan as a Delivery System
Journal of Microbiology and Biotechnology
2015 .01
-
Induction of Cytotoxic T Lymphocyte Response against the Core and NS3 Genes of the Hepatitis C Virus in Balb/c Mice
Korean journal of biological sciences
1999 .01
-
Construction and Immunization of the Recombinant Baculovirus Based DNA Vaccine Using GP5 Gene of the Porcine Reproductive and Respiratory Syndrome Virus
한국미생물학회 학술대회논문집
2013 .05
-
The Characteristics of RNA Vaccine
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
ISSUES IN HUMAN VACCINE DEVELOPMENT
한국동물학회 학술대회
1999 .01
-
Recombinant Virus-like Particle Vaccines and Universal Influenza Vaccination
한국미생물학회 학술대회논문집
2012 .05
-
DNA Vaccine Using the Modified L1 of Vaccinia Virus
한국미생물학회 학술대회논문집
2011 .05
-
The Tumor Protection of Human Papillomavirus E6/E7 DNA Vaccine
한국미생물학회 학술대회논문집
2013 .05
-
The Tumor Protection of Human Papillomavirus E6/E7 DNA Vaccine
한국미생물학회 학술대회논문집
2013 .05
-
The Tumor Protection of Human Papillomavirus E6/E7 DNA Vaccine
한국미생물학회 학술대회논문집
2014 .04
-
Oxidized Carbon Nanosphere-Based Subunit Vaccine Delivery System Elicited Robust Th1 and Cytotoxic T Cell Responses
Journal of Microbiology and Biotechnology
2019 .01
-
Vaccine Development Program for Developing Countries, International Vaccine Institute
한국미생물학회 학술대회논문집
2016 .04
-
Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis
Journal of Microbiology and Biotechnology
2018 .01
-
Tracking Study About Adenovirus 36 Infection: Increase of Adiposity
Journal of Microbiology and Biotechnology
2015 .01
-
동물세포배양을 통한 백신 생산의 현황과 미래전망
한국미생물·생명공학회지
2010 .01
-
Resistance against white spot syndrome virus (WSSV) infection in wild marine crab Gaetice depressus by injection of recombinant VP28 protein
한국어병학회지
2014 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0