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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 591 - 599 (9page)
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초록· 키워드
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A murine model immunized by systemic and mucosal delivery of plasmid DNA vaccine expressing glycoprotein B (pCIgB) of pseudorabies virus (PrV) was used to evaluate both the nature of the induced immunity and protection against a virulent virus. With regard to systemic delivery, the intramuscular (i.m.) immunization with pCIgB induced strong PrV-specific IgG responses in serum but was inefficient in generating a mucosal IgA response.
Mucosal delivery through intranasal (i.n.) immunization of pCIgB induced both systemic and mucosal immunity at the distal mucosal site. However, the levels of systemic immunity induced by i.n. immunization were less than those induced by i.m. immunization. Moreover, i.n. genetic transfer of pCIgB appeared to induce Th2-biased immunity compared with systemic delivery, as judged by the ratio of PrV-specific IgG isotypes and Th1- and Th2-type cytokines produced by stimulated T cells. Moreover, the immunity induced by i.n. immunization did not provide effective protection against i.n. challenge of a virulent PrV strain, whereas i.m. immunization produced resistance to viral infection. Therefore, although i.n. immunization was a useful route for inducing mucosal immunity at the virus entry site, i.n. immunization did not provide effective protection against the lethal infection of PrV.
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참고문헌 (23)
참고문헌 신청
Abbas, A. K. / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Bianchi, A. T. / 1998 / A mouse model to study immunity against pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~
Davis, S. S. / 2001 / Nasal vaccines. Adv. Drug Deliv / Rev 51 : 21 ~ 42
Donnelly, J. J. / 1997 / DNA vaccines. Annu. Rev / Immunol 15 : 617 ~ 648
Dory, D. / 2005 / Effective protection of pigs against lethal pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC a
Bianchi, A. T. / 1998 / A mouse model to study immunity against pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity / Vaccine 16 : 1550 ~
Davis, S. S. / 2001 / Nasal vaccines. Adv. Drug Deliv / Rev 51 : 21 ~ 42
Donnelly, J. J. / 1997 / DNA vaccines. Annu. Rev / Immunol 15 : 617 ~ 648
Dory, D. / 2005 / Effective protection of pigs against lethal pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC a
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