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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제1호
- 발행연도
- 2008.1
- 수록면
- 35 - 42 (8page)
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초록· 키워드
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Vibrio vulnificus produces siderophores, low-molecularweight
iron-chelating compounds, to obtain iron under
conditions of iron deprivation. To identify genes associated
with the biosynthesis of siderophore in V. vulnificus MO6-
24/O, we screened clones with mini-Tn5 random insertions
for those showing decreased production of siderophore.
Among 6,000 clones screened, nine such clones were
selected. These clones contain the transposon inserted in
VV2_0830 (GenBank accession number) that is a homolog
of a nonribosomal peptide synthase (NRPS). There is an
another NRPS module, VV2_0831, 49-bp upstream to
VV2_0830. We named these two genes vvs (Vibrio vulnificus
siderophore synthase) A and B, respectively. Mutation of
either vvsA or vvsB showed a decreased production of
siderophore. The expression of an NRPS-lux fusion was
negatively modulated by the presence of iron, and the
regulation was dependent on Fur (ferric uptake regulator).
However, the expression of the NRPS genes was still not
fully derepressed in the iron-rich condition, even in furnull
mutant cells, suggesting that some other unknown
factors are involved in the regulation of the genes. We also
demonstrated that the NRPS genes are important for
virulence of the pathogen in a mice model.
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참고문헌 (24)
참고문헌 신청
Aisen, P. / 1972 / Molecular weight and subunit structure of hagfish transferrin / Biochemistry 11 : 3461 ~ 3464
Biosca, E. G. / 1996 / Siderophore-mediated iron acquisition mechanisms in Vibrio vulnificus biotype 2. Appl. Environ / Microbiol 62 : 928 ~ 935
Butterton, J. R. / 1992 / Cloning, sequencing, and transcriptional regulation of viuA, the gene encoding the ferric vibriobactin receptor of Vibrio cholerae. J / Bacteriol 17
Butterton,J.R.,M.H.Choi,P.I.Watnick,P.A.Carroll,and S.B.Calderwood / 2000 / Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonri
Choi, H. K. / 2002 / Promoter analysis and regulatory characteristics of vvhBA encoding cytolytic hemolysin of Vibrio vulnificus. J. Biol / Chem 277 : 47292 ~ 47299
Biosca, E. G. / 1996 / Siderophore-mediated iron acquisition mechanisms in Vibrio vulnificus biotype 2. Appl. Environ / Microbiol 62 : 928 ~ 935
Butterton, J. R. / 1992 / Cloning, sequencing, and transcriptional regulation of viuA, the gene encoding the ferric vibriobactin receptor of Vibrio cholerae. J / Bacteriol 17
Butterton,J.R.,M.H.Choi,P.I.Watnick,P.A.Carroll,and S.B.Calderwood / 2000 / Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonri
Choi, H. K. / 2002 / Promoter analysis and regulatory characteristics of vvhBA encoding cytolytic hemolysin of Vibrio vulnificus. J. Biol / Chem 277 : 47292 ~ 47299
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