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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제4호
- 발행연도
- 2010.1
- 수록면
- 708 - 711 (4page)
이용수
초록· 키워드
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We report the isolation and characterization of a novel knottin-type antimicrobial peptide from the yellow-spotted long-horned beetle Psacothea hilaris. A cDNA encoding a 56-mer knottin-type propeptide was identified and its predicted molecular mass and pI were 5.92 kDa and 8.28,respectively. A 34-mer mature peptide was also selected and named herein as psacotheasin. The antimicrobial activity of chemically synthesized psacotheasin against human bacterial pathogens was subsequently investigated.
The results showed that psacotheasin exerted potent activities against both Gram-positive and Gram-negative bacterial strains. The present study suggests that psacotheasin can be applied to develop novel therapeutic agents.
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참고문헌 (12)
참고문헌 신청
Blondelle, S. E / 1991 / Hemolytic and antimicrobial activities of the twenty-four individual omission analogues of melittin / Biochemistry 30 : 4671 ~ 4678
Bulet, P / 1999 / Antimicrobial peptides in insects; structure and function / Dev. Comp. Immunol 23 : 329 ~ 344
Clinical and Laboratory Standards Institute / 2005 / Performance Standards for Antimicrobial Susceptibility Testing / Fifteenth Informational Supplement
Hultmark, D / 1993 / Immune reactions in Drosophila and other insects: A model for innate immunity / Trends Genet 9 : 178 ~ 183
Juneyoung Lee / 2008 / Structure-antimicrobial activity relationship between pleurocidin and its enantiomer / Experimental and Molecular Medicine 40 (4) : 370 ~ 376
Bulet, P / 1999 / Antimicrobial peptides in insects; structure and function / Dev. Comp. Immunol 23 : 329 ~ 344
Clinical and Laboratory Standards Institute / 2005 / Performance Standards for Antimicrobial Susceptibility Testing / Fifteenth Informational Supplement
Hultmark, D / 1993 / Immune reactions in Drosophila and other insects: A model for innate immunity / Trends Genet 9 : 178 ~ 183
Juneyoung Lee / 2008 / Structure-antimicrobial activity relationship between pleurocidin and its enantiomer / Experimental and Molecular Medicine 40 (4) : 370 ~ 376
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