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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제1호
- 발행연도
- 2010.1
- 수록면
- 30 - 38 (9page)
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The contribution of a type II restriction-modification system (R-M system) to genome integrity and cell viability was investigated. We established experimental conditions that enabled the achievement of hemimethylated and unmethylated states for the specific bases of the recognition sequences of the host’s DNA. To achieve this, we constructed the MboII R-M system containing only one (i.e., M2.MboII)out of two functional MboII methyltransferases found in Moraxella bovis. Using the incomplete R-M system, we were able to perturb the balance between methylation and restriction in an inducible manner. We demonstrate that upon the SOS-induced DNA repair in mitomycin C treated cells, restriction significantly reduces cell viability.
Similar results for the well-studied wild-type EcoRI R-M system, expressed constitutively in Escherichia coli, were obtained. Our data provide further insights into the benefits and disadvantages of maintaining of a type II RM system, highlighting its impact on host cell fitness.
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참고문헌 (23)
참고문헌 신청
Aras, R. A / 2001 / Regulation of the HpyII restriction-modification system of Helicobacter pylori by gene deletion and horizontal reconstitution / Mol. Microbiol 42 : 369 ~
Aras, R. A / 2002 / Helicobacter pylori interstrain restriction-modification diversity revents genome subversion by chromosomal DNA from competing strain / Nucleic Acids Res
Blakely, G. W / 2006 / Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recom
Blattner, F. R / 1997 / The complete genome sequence of Escherichia coli K-12 / Science 277 : 1453 ~ 1462
Bocklage, H / 1991 / Cloning and characterization of the MboII restriction-modification system / Nucleic Acids Res 19 : 1007 ~ 1013
Aras, R. A / 2002 / Helicobacter pylori interstrain restriction-modification diversity revents genome subversion by chromosomal DNA from competing strain / Nucleic Acids Res
Blakely, G. W / 2006 / Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recom
Blattner, F. R / 1997 / The complete genome sequence of Escherichia coli K-12 / Science 277 : 1453 ~ 1462
Bocklage, H / 1991 / Cloning and characterization of the MboII restriction-modification system / Nucleic Acids Res 19 : 1007 ~ 1013
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