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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제11호
- 발행연도
- 2009.1
- 수록면
- 1,364 - 1,368 (5page)
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초록· 키워드
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Lysosomes, as a cell organelle type, are safe biological
control agents that may be possible replacements for
chemical antimicrobial agents because they are simply
isolated from egg white. In this study, it was found that the
lysosomes isolated from egg white exhibited pH-dependent
antimicrobial activity, with the optimal activity found at
pH 6.0. The efficiency of lysosomes in inhibiting bacterial
growth and activity was evaluated over a 12-h treatment
period. Seven different microorganisms were used as
bacterial strains, and the lysosomes showed a significant
antimicrobial effect against all strains. In addition, the
antimicrobial activity was maintained for 100 days, and
there did not appear to be any resistance of E. coli to the
lysosomal activity up to the eighth culture. However, the
lysosomes did not affect the viability of mammalian cells,
suggesting the biocompatibility of lysosomes. These highly
effective lysosomes have a bright future in the application
of novel antimicrobial sources as a cell organelle type.
목차
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참고문헌 (15)
참고문헌 신청
Bruce, A. / 2002 / Molecular Biology of the Cell / Garland Science
Coleman, S. E. / 1970 / Lysis of grouped and ungrouped Streptococci by lysozyme / Infect. Immun 2 : 563 ~ 569
Dunn, W. A. Jr / 1994 / Autophagy and related mechanisms of lysosome-mediated protein degradation / Trends Cell Biol 1994 : 139 ~ 143
Gallis, H. A. / 1976 / Degradation of 14C-labeled streptococcal cell walls by egg white lysozyme and lysosomal enzymes / Infect. Immun 13 : 1459 ~ 1466
Glick, A. D. / 1972 / Degradation of group A streptococcal cell walls by egg-white lysozyme and human lysosomal enzymes / Infect. Immun 6 : 403 ~ 413
Coleman, S. E. / 1970 / Lysis of grouped and ungrouped Streptococci by lysozyme / Infect. Immun 2 : 563 ~ 569
Dunn, W. A. Jr / 1994 / Autophagy and related mechanisms of lysosome-mediated protein degradation / Trends Cell Biol 1994 : 139 ~ 143
Gallis, H. A. / 1976 / Degradation of 14C-labeled streptococcal cell walls by egg white lysozyme and lysosomal enzymes / Infect. Immun 13 : 1459 ~ 1466
Glick, A. D. / 1972 / Degradation of group A streptococcal cell walls by egg-white lysozyme and human lysosomal enzymes / Infect. Immun 6 : 403 ~ 413
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