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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,613 - 1,619 (7page)
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It has been reported that Tat-SOD can be directly transduced into mammalian cells and skin and acts as a potential therapeutic protein in various diseases. To isolate the compound that can enhance the transduction efficiency of Tat-SOD, we screened a number of natural products.
3-O-[β-D-Glucopyranosyl(1→4)-α-L-arabinopyranosyl]- hederagenin (OGAH) was identified as an active component of Fatsia japonica and is known as triterpenoid glycosides (hederagenin saponins). OGAH enhanced the transduction efficiencies of Tat-SOD into HeLa cells and mice skin. The enzymatic activities in the presence of OGAH were markedly increased in vitro and in vivo when compared with the controls. Although the mechanism is not fully understood, we suggest that OGAH, the active component of Fatsia japonica, might change the conformation of the membrane structure and it may be useful as an ingredient in antiaging cosmetics or as a stimulator of therapeutic proteins that can be used in various disorders related to reactive oxygen species (ROS).
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참고문헌 (25)
참고문헌 신청
Anguelakava, M. / 1972 / The cutaneous effect of phytoestrogen compounds of certain medicinal drugs. Part. Cosm / Sav 2 : 555 ~ 557
Bannister, J. V. / 1987 / Assays for superoxide dismutase. Methods Biochem / Anal 32 : 279 ~ 312
Bastiaanse, E. M. / 1997 / The effect of membrane cholesterol content on ion transport processes in plasma membranes. Cardiovasc / Res 33 : 272 ~ 283
Boll, P. M. / 1987 / On the presence of falcarinol in Araliaceae / Phytochemistry 26 : 2955 ~ 2956
Bradford, M. A. / 1979 / A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal / Biochem
Bannister, J. V. / 1987 / Assays for superoxide dismutase. Methods Biochem / Anal 32 : 279 ~ 312
Bastiaanse, E. M. / 1997 / The effect of membrane cholesterol content on ion transport processes in plasma membranes. Cardiovasc / Res 33 : 272 ~ 283
Boll, P. M. / 1987 / On the presence of falcarinol in Araliaceae / Phytochemistry 26 : 2955 ~ 2956
Bradford, M. A. / 1979 / A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal / Biochem
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