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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제5호
- 발행연도
- 2008.1
- 수록면
- 990 - 996 (7page)
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초록· 키워드
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In a previous study, we found an antifungal effect on human pathogenic fungi by the cell-penetrating peptide Tat (47-58) derived from HIV-1. Tat (47-58) immediately entered into the fungal nucleus and affected some physiological changes on the intracellular condition. In this study, Tat (47-58) showed a broad spectrum of antibacterial activity against pathogenic bacteria including bacterial clinical isolates. To improve resistance against proteases for use in vivo, we synthesized an analog of Tat (47-58) by substituting the L-amino acid for the D-amino acid. The D-enantiomer of Tat (47-58) also exhibited a broad spectrum of antibacterial activity at almost the same level of L-Tat (47-58) concentration. Unlike L-Tat (47-58), D-Tat (47-58) showed a significant proteolytic resistance against all proteases tested and antimicrobial activities in the presence of trypsin.
Moreover, D-Tat (47-58) inhibited MRSA infection in human HeLa cells whereas L-Tat (47-58) partially allowed MRSA infection, and the results were due to the proteolytic resistance of D-Tat (47-58).
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참고문헌 (24)
참고문헌 신청
Bechinger, B. / 1997 / Structure and functions of channel-forming peptides: Magainins, cecropins, melittin and alamethicin. J. Membr / Biol 156 : 197 ~ 211
Bessin, Y. / 2004 / Antibacterial activity and pore-forming properties of ceratotoxins: A mechanism of action based on the barrel stave model. Biochim. Biophys / Acta 1667 :
Blondelle, S. E. / 1992 / Design of model amphipathic peptides having potent antimicrobial activities / Biochemistry 31 : 12688 ~ 12694
Boman, H. G. / 1993 / Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect / Immun 61 : 2978 ~ 2984
Brugidou, J. / 1995 / The retro-inverso form of a homeobox-derived short peptide is rapidly internalized by cultured neurons: A new basis for an efficient intracellular deliv
Bessin, Y. / 2004 / Antibacterial activity and pore-forming properties of ceratotoxins: A mechanism of action based on the barrel stave model. Biochim. Biophys / Acta 1667 :
Blondelle, S. E. / 1992 / Design of model amphipathic peptides having potent antimicrobial activities / Biochemistry 31 : 12688 ~ 12694
Boman, H. G. / 1993 / Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect / Immun 61 : 2978 ~ 2984
Brugidou, J. / 1995 / The retro-inverso form of a homeobox-derived short peptide is rapidly internalized by cultured neurons: A new basis for an efficient intracellular deliv
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