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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제8호
- 발행연도
- 2008.1
- 수록면
- 1,427 - 1,430 (4page)
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Decursinol, found in the roots of Angelica gigas Nakai,
has been traditionally used to treat anemia and other
various diseases. Recently, numerous biological activities
such as cytotoxic effect on leukemia cells, and antitumor,
neuroprotection, and antibacterial activities have been
reported for this compound. Although a number of proteins
including protein kinase C, androgen receptor, and
acetylcholinesterase were proposed as molecular targets
responsible for the activities of decursinol, they are not
enough to explain such a diverse biological activity
mentioned above. In this study, we employed a chemical
proteomic approach, leading to identification of seven
proteins as potential proteins interacting with decursinol.
Most of the proteins contain a defined ATP or nucleic acid
binding domain and have been implied to be involved in
the pathogenesis and progression of various human diseases
including cancer, autoimmune disorders, or neurodegenerative
diseases. The present results may provide clues to understand
the molecular mechanism of the biological activities shown
by decursinol, an anticancer natural product.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] -
Ahn, K. S. / 1997 / Decursinol angelate. A cytotoxic and protein kinase C activating agent from the root of Angelica gigas / Planta Med 63 : 360 ~ 361
Ahn, K.-S. / 1995 / Detection of anticancer activity from the root of Angelica gigas in vitro. J. Microbiol / Biotechnol 5 : 105 ~ 109
Bae, E.-A. / 1998 / Anti- Helicobacter pylori activity of herbal medicines. Biol. Pharm / Bull 21 : 990 ~ 992
CHOI, IN-KWON / 2007 / Streptochlorin, a Marine Natural Product, Inhibits NF-κB Activation andSuppresses Angiogenesis In Vitro / Journal of Microbiology and Biotechnology 17
Ahn, K. S. / 1997 / Decursinol angelate. A cytotoxic and protein kinase C activating agent from the root of Angelica gigas / Planta Med 63 : 360 ~ 361
Ahn, K.-S. / 1995 / Detection of anticancer activity from the root of Angelica gigas in vitro. J. Microbiol / Biotechnol 5 : 105 ~ 109
Bae, E.-A. / 1998 / Anti- Helicobacter pylori activity of herbal medicines. Biol. Pharm / Bull 21 : 990 ~ 992
CHOI, IN-KWON / 2007 / Streptochlorin, a Marine Natural Product, Inhibits NF-κB Activation andSuppresses Angiogenesis In Vitro / Journal of Microbiology and Biotechnology 17
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