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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제6호
- 발행연도
- 2007.1
- 수록면
- 1,024 - 1,030 (7page)
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초록· 키워드
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We investigated the human apolipoprotein E2(apoE2) transgenic mouse as an animal model system for age-related macular degeneration (AMD). Transgenic mice expressinghuman apoE2 and C57BL/6J mice were fed normal chow or ahigh-fat diet for 4 weeks. Eyes were collected from the miceand lipid deposits in retinal pigment epithelium (RPE) werevascular endothelial growth factor (VEGF), basic fibroblastgrowth factor (bFGF), and pigment-epithelium derived factor(PEDF), which are molecular markers for angiogenesis, wereasesed with imunohistochemistry. Eyes from apoE2 mice,regardles of diet, contained lipid accumulation in RPE underelectron microscopy, whereas control C57BL/6J eyes did not.Lipid acumulation was found predominantly in the RPE andthe Bruch’s membrane and increased in the eyes of apoE2mice after one month of a high-fat diet (8±2 per 50m2 fornormal chow and 1±2 per 50m2, p<0.05). ApoE expressionwas similar in the apoE2 and control mice; however, VEGFand bFGF were overexpressed in the retinal pigmentepithelium of apoE2 eyes compared with control eyes, andPEDF expression was slightly decreased. These expressionpatterns of VEGF, bFGF, and PEDF suggest angiogenesis isprogressing in apoE2 eyes. In conclusion, the eyes of apoE2 miceof AMD, making them a suitable animal model for AMD.The expression profile of VEGF and bFGF on the retinal pigmentepithelium suggests that apoE2 may induce neovascularizationby altering angiogenic cytokines.
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참고문헌 (27)
참고문헌 신청
A / 1986 / Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis : 57 ~ 61 66
A / 1991 / Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree : 643 ~ 655
Algvere, P. V / 2003 / Drusen maculopathy: A risk factor for AMD. Can we prevent visual loss? 81 : 427 ~ 429
Amano, S / 2005 / Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes 69 : 45 ~ 55
Bhutto. I. A / 2006 / Pigment epitheliumderived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with agerelated macular degeneratio
A / 1991 / Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree : 643 ~ 655
Algvere, P. V / 2003 / Drusen maculopathy: A risk factor for AMD. Can we prevent visual loss? 81 : 427 ~ 429
Amano, S / 2005 / Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes 69 : 45 ~ 55
Bhutto. I. A / 2006 / Pigment epitheliumderived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with agerelated macular degeneratio
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