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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 311 - 318 (8page)
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초록· 키워드
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In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H )-quinolinone (cilostazol) and Ginkgo biloba extract (GbE)was examined in apolipoprotein E (ApoE) null mice.
Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE.
Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis.
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참고문헌 (20)
참고문헌 신청
Altiok N / 2006 / Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin / Neurotoxicology 27 : 158 ~ 163
Aoki C / 2010 / Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo / J Atheroscler Thromb 17 : 503 ~ 509
Chen JW / 2003 / Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion mol
Cybulsky MI / 2001 / A major role for VCAM-1, but not ICAM-1, in early atherosclerosis / J Clin Invest 107 : 1255 ~ 1262
Gomez CR / 2009 / Medical treatment of patients with intracranial atherosclerotic disease / J Neuroimaging 19 : 25S ~ 29S
Aoki C / 2010 / Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo / J Atheroscler Thromb 17 : 503 ~ 509
Chen JW / 2003 / Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion mol
Cybulsky MI / 2001 / A major role for VCAM-1, but not ICAM-1, in early atherosclerosis / J Clin Invest 107 : 1255 ~ 1262
Gomez CR / 2009 / Medical treatment of patients with intracranial atherosclerotic disease / J Neuroimaging 19 : 25S ~ 29S
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