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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제6호
- 발행연도
- 2005.1
- 수록면
- 1,384 - 1,387 (4page)
이용수
초록· 키워드
오류제보하기
Hantavax is one of the killed Hantavirus vaccines,and is commercially available in South Korea. This vaccinewas developed by inactivation of virus isolated from infectedsuckling mouse brain with formalin. Although Hantavaxcan induce neutralizing antibodies in vaccinees, the strengthof this induction and the duration of the humoral immuneresponse are controversial issues. In this study, we studied thenative conformation of the killed vaccine by antigen-capturereverse transcriptase polymerase chain reaction with patientand vaccinee sera containing neutralizing antibodies againstHantavirus. The results showed that Hantavax could bindHTNV patient and vaccinee sera like live virus, suggestingthat the integrity of the viral epitope is maintained inHantavax and induces the protective antibodies, eventhough the virus was inactivated with formalin.
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참고문헌 (13)
참고문헌 신청
/ 1978 / Isolation ofthe etiologic agent of Korean hemorrhagic fever : 298 ~ 302
/ 1990 / Molecularepidemiology of human hepatitis A virus defined by anantigen-capture polymerase chain reaction method 87 : 2867 ~ 87 2871
/ 1994185-196 / Prospects for vaccines to controlviruses in the family Bunyaviridae
/ 1995 / Production and characterization of monoclonal antibodiesto Hantaan virus and Seoul virus 25 : 59 ~ 71
/ 1999 / Antibody responses inhumans to an inactivated hantavirus vaccine 17 : 2569 ~ 17 2575
/ 1990 / Molecularepidemiology of human hepatitis A virus defined by anantigen-capture polymerase chain reaction method 87 : 2867 ~ 87 2871
/ 1994185-196 / Prospects for vaccines to controlviruses in the family Bunyaviridae
/ 1995 / Production and characterization of monoclonal antibodiesto Hantaan virus and Seoul virus 25 : 59 ~ 71
/ 1999 / Antibody responses inhumans to an inactivated hantavirus vaccine 17 : 2569 ~ 17 2575
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