지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 363 - 367 (5page)
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초록· 키워드
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Cross-reactive neutralizing antibodies against influenza A viruses have received attention for their potentials for prophylactic and therapeutic. These antibodies usually bind to relatively conserved stem domains of influenza hemagglutinin, one of surface glycoproteins responsible for viral binding to sialic acid-tagged cellular receptors and for membrane fusion to initiate a release process of viral genomes inside cells. Recently, a similar approach extended to influenza B viruses, which causing annual epidemics only in the human population, and some of human monoclonal antibodies exhibited promising efficacies against two antigenically diverged lineages of influenza B viruses. Moreover, one of these broadly neutralizing antibodies protected mice against both of influenza A and B challenges. Appropriate immunization may selectively enhance the efficacy of these antibodies, and this strategy may lead individuals to be prepared with broad immune responses against various influenza viruses.
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UCI(KEPA) : I410-ECN-0101-2014-475-000463196