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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 117 - 123 (7page)
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In this study, to evaluate the anti-oxidative and anti-inflammatory effects of Carpinus pubescens Burkill ethanol extract (CPEE), we performed the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) inhibition, and nitric oxide (NO) scavenging assays and an analysis of the related protein expressions. CPEE showed high DPPH radical scavenging activity and effectively increased ROS inhibition activity dose-dependently. Furthermore, CPEE induced the expression of the anti-oxidative enzyme heme oxygenase 1 and its upstream transcription factor, nuclear factor-E2-related factor 2, in RAW 264.7 cells. CPEE was associated with a reduction in NO production, which was induced by lipopolysaccharide treatment in a dose-dependent manner. The expression of inducible nitric oxide synthase (iNOS), an upstream regulator of NO production, was also inhibited. Taken together, these results suggest that CPEE has anti-oxidative and anti-inflammatory activities and could be useful as a potential anti-oxidant and antiinflammatory agent.
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참고문헌 (43)
참고문헌 신청
안선일 / 2007 / 일부 페놀성 화합물의 항산화효과 및 아질산염 소거능 / 한국식품조리과학회지 23(1):19~24
Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horiz 3:46~64
Balogun E / 2003 / Curcumin activates the heme oxygenase-1 gene via regulation of Nrf2 and the antioxidant responsive element / Biochem. J 371:887~895
Chen XL / 2004 / Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory iseases / Curr. Pharm. Des 10:879~891
정은경 / 2011 / 유기농 콩 추출물의 항염증 및 항알레르기 효과 / 한국유기농업학회지 19(2):245~253
Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horiz 3:46~64
Balogun E / 2003 / Curcumin activates the heme oxygenase-1 gene via regulation of Nrf2 and the antioxidant responsive element / Biochem. J 371:887~895
Chen XL / 2004 / Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory iseases / Curr. Pharm. Des 10:879~891
정은경 / 2011 / 유기농 콩 추출물의 항염증 및 항알레르기 효과 / 한국유기농업학회지 19(2):245~253
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